High-sensitive nonlinear detection of steroids by resonant double grating waveguide structures-based immunosensors

Autor:	K N Anisha Thayil, M.-Pilar Marco, Silvia Soria, Roger Galve, Pablo Loza-Alvarez, Alejandro Muriano, J.-Pablo Salvador
Rok vydání:	2011
Předmět:	Detection limit Materials science business.industry Grating High sensitive Chip law.invention Nonlinear system Optics law business Luminescence Waveguide Order of magnitude
Zdroj:	Photonics West: Integrated Optics: Devices, Materials, and Technologies XVI, 2011 info:cnr-pdr/source/autori:Alejandro Muriano, J.-Pablo Salvador, Roger Galve, M.-Pilar Marco, Anisha Thayil K.N., Pablo Loza-Alvarez, Silvia Soria/congresso_nome:Photonics West: Integrated Optics: Devices, Materials, and Technologies XVI/congresso_luogo:/congresso_data:2011/anno:2011/pagina_da:/pagina_a:/intervallo_pagine
ISSN:	0277-786X
DOI:	10.1117/12.876456
Popis:	We report the non linear fluorescence real-time detection of methylboldenone, an androgenic anabolic steroid used illegally as growth promoter based on a resonant sensing chip: a double grating waveguide structure. The limit of detection of this synthetic steroid is two orders of magnitude lower than the Minimum Required Performance Limit required by the World Anti-Doping Agency. The immunoreagents have been have been immobilized onto the surface of the resonant sensor after being activated with phosphonohexanoic acid spacers. The developed immunosensor presents great potential as a robust sensing device for fast and early detection of illegal dopants and food contaminants.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3bf0419713cdf3d4ac3cecf5ed9cf42 https://doi.org/10.1117/12.876456 Zobrazit plný text záznamu