Insulin resistance in critically ill patients with acute renal failure
| Autor: | Jonathan Himmelfarb, Yu Shyr, Stephanie Freedman, Lara B. Pupim, Edith M. Simmons, Ravindra L. Mehta, M. Tugrul Sezer, Seema Basi, Emil P. Paganini, Glenn M. Chertow, T. Alp Ikizler |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Adolescent Physiology Adverse outcomes Urinary system Critical Illness Insulin resistance Predictive Value of Tests Somatomedins Hyperinsulinism medicine Humans Insulin Survivors Intensive care medicine Aged Insulin blood Critically ill business.industry Extramural Hemodynamics Acute Kidney Injury Middle Aged medicine.disease Insulin-Like Growth Factor Binding Protein 1 Insulin-Like Growth Factor Binding Protein 3 Logistic Models Hyperglycemia Critical illness Female Insulin Resistance business Kidney disease Signal Transduction |
| Zdroj: | American journal of physiology. Renal physiology. 289(2) |
| ISSN: | 1931-857X |
| Popis: | Mortality in critically ill patients with acute renal failure (ARF) remains high. Hyperglycemia associated with insulin resistance has been associated with adverse outcomes in critically ill intensive care unit (ICU) patients but has not been examined specifically in patients with ARF. We used data from a subcohort ( n = 90) of the Program to Improve Care in Acute Renal Disease (PICARD), an observational study of 618 adult ICU patients with ARF in whom nephrology service consultation was obtained. We obtained simultaneous measurements of serum glucose, insulin, insulin-like growth factor (IGF)-I, and IGF-1 binding proteins (IGFBP) in 90 patients. Daily glucose determinations were obtained from a larger fraction of the PICARD cohort ( n = 509). Among the 90 patients with intensive metabolic monitoring, glucose concentrations in survivors were significantly lower than in nonsurvivors throughout the 5-wk period ( P = 0.008, adjusted P = 0.013). In the larger PICARD cohort ( n = 509), hyperglycemia was also significantly associated with in-hospital mortality. Mean insulin concentrations were significantly higher (431 ± 508 vs. 234 ± 189 pmol/l, P = 0.03), mean homeostasis model of insulin resistance levels were significantly higher (24.1 ± 30.0 vs. 11.7 ± 12.5, P = 0.04), and IGFBP-3 concentrations were significantly lower (1,190 ± 498 vs. 1,470 ± 581 μg/l, P = 0.02) among nonsurvivors compared with survivors. Insulin resistance as defined by hyperglycemia in the setting of higher insulin concentrations may be associated with mortality in critically ill patients with ARF. The IGF-IGFBP axis may play an important role in this process. |
| Databáze: | OpenAIRE |
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