Early life adversity is associated with elevated levels of circulating leptin, irisin, and decreased levels of adiponectin in midlife adults
| Autor: | Kyoung Eun Joung, Kyung Hee Park, Nicole Usher, Judith A. Crowell, Christos S. Mantzoros, Ayse Sahin-Efe, Dorothy E. Warner, Mary Brinkoetter, Cynthia Davis, Lesya Zaichenko, Bindiya Thakkar |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Leptin Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Context (language use) Biochemistry Life Change Events Endocrinology Internal medicine medicine Humans Child Abuse Child Adiponectin business.industry Biochemistry (medical) Type 2 Diabetes Mellitus JCEM Online: Brief Reports Middle Aged medicine.disease Obesity Fibronectins C-Reactive Protein Cross-Sectional Studies Sexual abuse Female Metabolic syndrome business Body mass index Stress Psychological |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 99(6) |
| ISSN: | 1945-7197 |
| Popis: | Early-life adversity, defined as physical, emotional, or sexual abuse and neglect before 18 years of age, is associated with metabolic syndrome, obesity, and type 2 diabetes mellitus in adult life. However, the underlying mechanism is not fully understood, and whether adipomyokines are associated with early-life adversity independent of other factors such as body mass index, psychosocial risks, and health behaviors is not known.The objective of the study was to evaluate the association between early-life adversity and circulating the levels of the adipomyokines such as leptin, adiponectin, and irisin and the inflammatory marker, C-reactive protein (CRP). DESIGN/SUBJECTS/SETTING: This study was a cross-sectional study of 95 adults at a university-based research center. We collected venous blood from participants and analyzed serum for leptin, adiponectin, irisin, and CRP.Circulating leptin, irisin, and CRP levels were significantly higher in the highest adversity tertile group compared with low and middle tertile groups (P.001 for leptin, P = .01 for irisin, and P = .02 for CRP). Adiponectin levels were lower in the highest tertile group compared with the low and middle tertile groups (P = .03). After adjusting for demographic variables, physical activity, diet, current mental health, and body mass index, the associations between early-life adversity leptin, irisin, and did not change. However, adiponectin and CRP levels were no longer significantly related to early life adversity.Early-life adversity is directly associated with elevated circulating leptin and irisin, and indirectly associated with elevated CRP and decreased adiponectin. These findings suggest that these adipomyokines may play a role in the pathogenesis of metabolic abnormality in a population with significant early life adversity. |
| Databáze: | OpenAIRE |
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