Effects of Alcohol Intake and Low Km Aldehyde Dehydrogenase on Hepatic Function in a High Hepatitis C Virus-Prevalent Japanese Island Population
| Autor: | Shigeaki Sato, Xing Yang, Mari Hirata, Kanehisa Morimoto, Tatsuya Takeshita |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Alcohol Drinking Genotype Hepatitis C virus Population Medicine (miscellaneous) Aldehyde dehydrogenase Physiology Aspartate transaminase Comorbidity Toxicology medicine.disease_cause Flaviviridae Sex Factors Asian People Japan Liver Function Tests medicine Humans education Liver Diseases Alcoholic ALDH2 Liver injury Genetics education.field_of_study biology Aldehyde Dehydrogenase Hepatitis C Chronic Middle Aged medicine.disease biology.organism_classification digestive system diseases Psychiatry and Mental health biology.protein Female Liver function |
| Zdroj: | Alcoholism: Clinical and Experimental Research. 23:751-756 |
| ISSN: | 1530-0277 0145-6008 |
| DOI: | 10.1111/j.1530-0277.1999.tb04179.x |
| Popis: | In Asians from the Pacific rim countries, alcohol sensitivity has been attributed mainly to a highly prevalent polymorphism in low K m aldehyde dehydrogenase (ALDH2). Chronic alcohol abuse may accelerate or aggravate the liver injury in chronic hepatitis C virus (HCV)-infected subjects. In this study, we examined the relationships among alcohol intake, ALDH2 genotypes, and liver injury in a high HCV-prevalent Japanese native island population. The ALDH2 genotypes are significantly associated with drinking habits. In HCV RNA positive subjects, serum alanine aminotransferase (ALT), as well as aspartate transaminase (AST) and γ-glutamyl transpeptidase (GGT), were significantly higher in habitual drinkers than in nonhabitual drinkers. In male habitual drinkers, the ALDH2 * 1/ * 1 subjects had higher liver necroinflammatory scores than the ALDH2 * 1/ * 2 subjects in all groups classified as: I, anti-HCV-seronegative; II, anti-HCV-seropositive with negative HCV RNA; and III, HCV RNA positive, although scores for the latter two groups were not statistically significant because of limited sample size. It was suggested that the liver function might be affected by the interaction between the ALDH2 genotypes and alcohol intake. These findings indicate that HCV-infected ALDH2 * 1/ * 1 habitual drinkers are the major target for the prevention of alcoholic liver diseases. |
| Databáze: | OpenAIRE |
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