Iron-binding antioxidant capacity is impaired in diabetes mellitus
| Autor: | Ann Van Campenhout, Christophe De Block, Greta Moorkens, Albert R. Lagrou, Begoña Manuel-y-Keenoy, Christel Van Campenhout |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Iron Type 2 diabetes Biochemistry Lipid peroxidation chemistry.chemical_compound Glycation Physiology (medical) Diabetes mellitus Internal medicine medicine Humans Aged Glycemic chemistry.chemical_classification medicine.diagnostic_test biology Chemistry Transferrin Middle Aged medicine.disease Diabetes Mellitus Type 1 Endocrinology Diabetes Mellitus Type 2 Serum iron biology.protein Female Lipid Peroxidation Ceruloplasmin |
| Zdroj: | Free radical biology and medicine |
| ISSN: | 0891-5849 |
| DOI: | 10.1016/j.freeradbiomed.2006.01.010 |
| Popis: | Increased lipid peroxidation contributes to diabetic complications and redox-active iron is known to play an important role in catalyzing peroxidation reactions. We aimed to investigate if diabetes affects the capacity of plasma to protect against iron-driven lipid peroxidation and to identify underlying factors. Glycemic control, serum iron, proteins involved in iron homeostasis, plasma iron-binding antioxidant capacity in a liposomal model, and non-transferrin-bound iron were measured in 40 type 1 and 67 type 2 diabetic patients compared to 100 nondiabetic healthy control subjects. Iron-binding antioxidant capacity was significantly lower in the plasma of diabetic subjects (83 +/- 6 and 84 +/- 5% in type 1 and type 2 diabetes versus 88 +/- 6% in control subjects, p < 0.0005). The contribution of transferrin, ceruloplasmin, and albumin concentrations to the iron-binding antioxidant capacity was lost in diabetes (explaining only 4.2 and 6.3% of the variance in type 1 and type 2 diabetes versus 13.9% in control subjects). This observation could not be explained by differences in Tf glycation, lipid, or inflammatory status and was not associated with higher non-transferrin-bound iron levels. Iron-binding antioxidant capacity is decreased in diabetes mellitus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect