Predicting mental disorders from hypothalamic-pituitary-adrenal axis functioning

Autor: Johan Ormel, Esther M. C. Bouma, Odilia M. Laceulle, Albertine J. Oldehinkel, Esther Nederhof, F. V. A. van Oort
Přispěvatelé: Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Child and Adolescent Psychiatry / Psychology, Medical and Clinical Psychology
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
Rural Population
Hydrocortisone
Urban Population
Pituitary-Adrenal System
Neuropsychological Tests
public speaking task
CORTISOL AWAKENING RESPONSE
ADOLESCENTS
social stress test
Prospective Studies
Child
Applied Psychology
Netherlands
Substance dependence
Depression
Prognosis
CIDI
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry and Mental health
medicine.anatomical_structure
MORNING CORTISOL
Anxiety
Major depressive disorder
Female
medicine.symptom
Psychology
CONCORDANCE
Hypothalamic–pituitary–adrenal axis
Psychopathology
Hypothalamo-Hypophyseal System
medicine.medical_specialty
Cortisol awakening response
LIFE EVENTS
longitudinal
Substance-Related Disorders
1ST-EPISODE MAJOR DEPRESSION
PSYCHOSOCIAL STRESS
ANXIETY DISORDERS
psychiatric diagnosis
phobia
substance dependence
medicine
Humans
Saliva
Psychiatry
Social stress
Depressive Disorder
Major
prospective
medicine.disease
Logistic Models
general psychopathology
YOUNG
Follow-Up Studies
Zdroj: Psychological Medicine, 45(11), 2403-2412. Cambridge University Press
Psychological Medicine: A Journal for Research in Psychiatry and the Allied Sciences, 45(11), 2403-2412. CAMBRIDGE UNIV PRESS
ISSN: 0033-2917
DOI: 10.1017/s0033291715000392
Popis: BackgroundHypothalamic-pituitary-adrenal axis functioning, with cortisol as its major output hormone, has been presumed to play a key role in the development of psychopathology. Predicting affective disorders from diurnal cortisol levels has been inconclusive, whereas the predictive value of stress-induced cortisol concentrations has not been studied before. The aim of this study was to predict mental disorders over a 3-year follow-up from awakening and stress-induced cortisol concentrations.MethodData were used from 561 TRAILS (TRacking Adolescents’ Individual Lives Survey) participants, a prospective cohort study of Dutch adolescents. Saliva samples were collected at awakening and half an hour later and during a social stress test at age 16. Mental disorders were assessed 3 years later with the Composite International Diagnostic Interview (CIDI).ResultsA lower cortisol awakening response (CAR) marginally significantly predicted new disorders [odds ratio (OR) 0.77, p = 0.06]. A flat recovery slope predicted disorders with a first onset after the experimental session (OR 1.27, p = 0.04). Recovery revealed smaller, non-significant ORs when predicting new onset affective or anxiety disorders, major depressive disorder, or dependence disorders in three separate models, corrected for all other new onsets.ConclusionsOur results suggest that delayed recovery and possibly reduced CAR are indicators of a more general risk status and may be part of a common pathway to psychopathology. Delayed recovery suggests that individuals at risk for mental disorders perceived the social stress test as less controllable and less predictable.
Databáze: OpenAIRE
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