The Expression and Prognostic Significance of Cks1 in Salivary Cancer
| Autor: | Dan D. Hershko, Ofer Ben-Izhak, Avishai Golz, Rafael M. Nagler, Dimitri Ostrovsky |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Adolescent Adenocarcinoma Biology Immunoenzyme Techniques Pathogenesis Young Adult Ubiquitin Proliferating Cell Nuclear Antigen Biomarkers Tumor CDC2-CDC28 Kinases In Situ Nick-End Labeling medicine SKP2 Humans S-Phase Kinase-Associated Proteins Lymph node Pathological Aged Aged 80 and over TUNEL assay Carcinoma Acinar Cell Kinase Cancer General Medicine Middle Aged Prognosis Salivary Gland Neoplasms medicine.disease Cyclin-Dependent Kinases Survival Rate Ki-67 Antigen medicine.anatomical_structure Oncology Lymphatic Metastasis Carcinoma Squamous Cell Cancer research biology.protein Carcinoma Mucoepidermoid Female Tumor Suppressor Protein p53 Carrier Proteins |
| Zdroj: | Cancer Investigation. 27:512-520 |
| ISSN: | 1532-4192 0735-7907 |
| DOI: | 10.1080/07357900802239116 |
| Popis: | Cks1 is an essential factor in facilitating Skp2-dependent degradation of p27, but its role in salivary malignancies is unknown. Expression of cyclin-dependent kinase subunit 1 (Cks1) was examined in 64 salivary malignancies, compared with p27, S-phase kinase protein 2 (Skp2), Ki-67, p53, and TDT-mediated dutp-biotin nick end labeling (TUNEL) expression, and with THE patient's clinical and pathological parameters. Cks1 expression was markedly increased in 30 patients (47%) and strongly correlated with increased expression of Skp2, Ki-67, p53, and TUNEL, but inversely with p27 levels. High expression of Cks1 WAS strongly associated with lymph node metastases and poor prognosis and survival. Cks1 alterations may have a significant biological role in the pathogenesis of salivary cancer. |
| Databáze: | OpenAIRE |
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