Omentin Val109Asp polymorphism and risk of coronary artery disease
| Autor: | Gholam Abbas Valizadeh, Ali Asnaashari, Nosaybeh Jafari, Javad Jamshidi, Mehrdad Ghanbari |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Pulmonary and Respiratory Medicine medicine.medical_specialty Genotype Subgroup analysis Coronary Artery Disease Iran 030204 cardiovascular system & hematology Coronary Angiography GPI-Linked Proteins Coronary artery disease 03 medical and health sciences Sex Factors 0302 clinical medicine Gene Frequency Risk Factors Lectins Internal medicine Odds Ratio Humans Medicine Allele Genotyping Polymorphism Genetic medicine.diagnostic_test Reverse Transcriptase Polymerase Chain Reaction business.industry Incidence DNA General Medicine Middle Aged medicine.disease Stenosis 030104 developmental biology medicine.anatomical_structure Case-Control Studies Angiography Cardiology Cytokines Population study Female Surgery Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | Asian Cardiovascular and Thoracic Annals. 25:199-203 |
| ISSN: | 1816-5370 0218-4923 |
| DOI: | 10.1177/0218492317699752 |
| Popis: | Background Omentin is an adipocytokine with antiinflammatory properties. It has been reported to be involved in atherosclerosis and coronary artery disease. We aimed to investigate the association of omentin Val109Asp polymorphism with coronary artery disease in an Iranian population. Methods For a case-control study, 400 individuals were recruited: 200 with coronary artery disease and 200 healthy controls. Patients with coronary artery disease were diagnosed by angiography as having at least one main coronary artery with more than 50% stenosis. Genotyping of Val109Asp was carried out using a polymerase chain reaction DNA-restriction fragment length polymorphism technique. Results There was no association between Val109Asp polymorphism and the risk of coronary artery disease in our study population ( p = 0.20). However, when subgroup analysis was performed according to sex, there was a significant difference in the distribution of alleles between groups for men ( p = 0.031, odds ratio = 0.57, 95% confidence interval: 0.35–0.95) but not for women ( p = 0.88, odds ratio = 1.03, 95% confidence interval: 0.66–1.61). Conclusions Our results indicate that the Asp allele of Val109Asp (T allele of rs2274907) is more frequent among men with coronary artery disease than healthy men, so it is possibly a risk factor for coronary artery disease in men only. The difference in association between men and women may be due to the different distribution and metabolism of adipose tissue in men and women. More studies with larger sample sizes and in different populations are required to validate our study results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|