Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice
| Autor: | Kaori Hitomi, Shiro Shibayama, Kanako Iwata, Masato Kubo, Akira Shibuya, Satoko Tahara-Hanaoka, Haruka Miki |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Immunology Immunoglobulin E Mice 03 medical and health sciences Respiratory Hypersensitivity medicine Animals Immunology and Allergy Mast Cells Receptors Immunologic Receptor Interleukin 4 Diphtheria toxin House dust mite Mice Inbred BALB C biology Chemistry Pyroglyphidae Degranulation General Medicine respiratory system medicine.disease biology.organism_classification respiratory tract diseases Mice Inbred C57BL 030104 developmental biology Mast cell sarcoma biology.protein Antibody |
| Zdroj: | International Immunology. 30:429-434 |
| ISSN: | 1460-2377 0953-8178 |
| Popis: | Although airway hyperresponsiveness (AHR) is a prominent feature of asthma, how it is regulated remains incompletely understood. Allergin-1, an inhibitory immunoglobulin-like receptor containing an immunoreceptor tyrosine-based inhibitory motif (ITIM), is expressed on human and mouse mast cells (MCs) and inhibits high-affinity receptor for IgE (FcεRI)-mediated signaling. Using MC-deficient KitW-sh/W-sh mice and Mas-TRECK mice, which carries a diphtheria toxin (DT)-induced MC deletion system based on il4 enhancer elements, we demonstrate here that MCs are involved in the induction of house dust mite (HDM)-induced AHR. Further, we show that MCs deficient in Allergin-1 exacerbated HDM-induced AHR, but had no effect on airway inflammation. In vitro analysis demonstrated that Allergin-1 inhibited anti-HDM allergen antibody-dependent HDM allergen-mediated degranulation by MCs. Thus, Allergin-1 on MCs plays an important role in the regulation of HDM-induced AHR. |
| Databáze: | OpenAIRE |
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