CD1d deficiency inhibits the development of abdominal aortic aneurysms in LDL receptor deficient mice
| Autor: | Kim L. L. Habets, Ilze Bot, Rosemarie E. van Bochove, Puck van Osch, Mariëtte N. D. ter Borg, Mariska Vos, Vivian de Waard, Johan Kuiper, Amanda C. Foks, Saskia C. A. de Jager, Gijs H.M. van Puijvelde, Louis Boon |
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| Přispěvatelé: | ACS - Amsterdam Cardiovascular Sciences, Medical Biochemistry |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Cell Activation Physiology medicine.medical_treatment lcsh:Medicine Apoptosis 030204 cardiovascular system & hematology Lymphocyte Activation Vascular Medicine Biochemistry Muscle Smooth Vascular White Blood Cells Mice Aortic aneurysm 0302 clinical medicine Animal Cells Immune Physiology Medicine and Health Sciences lcsh:Science Aorta Innate Immune System Multidisciplinary biology T Cells Angiotensin II hemic and immune systems Proteases Flow Cytometry Natural killer T cell Enzymes Cytokine CD1D cardiovascular system Cytokines Cellular Types Anatomy Aneurysms Cell activation Research Article Cell Physiology Immune Cells Immunology Antigen-Presenting Cells Mice Transgenic chemical and pharmacologic phenomena macromolecular substances Real-Time Polymerase Chain Reaction 03 medical and health sciences medicine.artery medicine Animals Vascular Diseases cardiovascular diseases Antigen-presenting cell Blood Cells business.industry Macrophages lcsh:R Biology and Life Sciences Proteins Cell Biology Molecular Development medicine.disease Mice Inbred C57BL 030104 developmental biology Receptors LDL Immune System Cardiovascular Anatomy Enzymology NIH 3T3 Cells Cancer research biology.protein Blood Vessels Natural Killer T-Cells lcsh:Q Antigens CD1d business Developmental Biology Aortic Aneurysm Abdominal |
| Zdroj: | Plos One PLoS ONE, 13(1). Public Library of Science Plos One, 13(1), e0190962 PLoS ONE PLoS ONE, Vol 13, Iss 1, p e0190962 (2018) |
| ISSN: | 1932-6203 |
| Popis: | An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta leading to serious complications and mostly to death. AAA development is associated with an accumulation of inflammatory cells in the aorta including NKT cells. An important factor in promoting the recruitment of these inflammatory cells into tissues and thereby contributing to the development of AAA is angiotensin II (Ang II). We demonstrate that a deficiency in CD1d dependent NKT cells under hyperlipidemic conditions (LDLr-/-CD1d-/- mice) results in a strong decline in the severity of angiotensin II induced aneurysm formation when compared with LDLr-/- mice. In addition, we show that Ang II amplifies the activation of NKT cells both in vivo and in vitro. We also provide evidence that type I NKT cells contribute to AAA development by inducing the expression of matrix degrading enzymes in vSMCs and macrophages, and by cytokine dependently decreasing vSMC viability. Altogether, these data prove that CD1d-dependent NKT cells contribute to AAA development in the Ang II-mediated aneurysm model by enhancing aortic degradation, establishing that therapeutic applications which target NKT cells can be a successful way to prevent AAA development. |
| Databáze: | OpenAIRE |
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