MELF Pattern for Predicting Lymph Node Involvement and Survival in Grade I-II Endometrioid-type Endometrial Cancer
| Autor: | Ozgu Gungorduk, Varol Gülseren, Tuğba Karadeniz, Mustafa Kocaer, Muzaffer Sanci, İsa Aykut Özdemir, Kemal Güngördük |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Biopsy medicine.medical_treatment Kaplan-Meier Estimate Disease-Free Survival Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Carcinoma medicine Humans Lymph node Aged Proportional Hazards Models Retrospective Studies Hysterectomy business.industry Proportional hazards model Endometrial cancer Hazard ratio Case-control study Obstetrics and Gynecology Odds ratio Middle Aged Prognosis medicine.disease Immunohistochemistry Endometrial Neoplasms 030104 developmental biology medicine.anatomical_structure Case-Control Studies Lymphatic Metastasis 030220 oncology & carcinogenesis Multivariate Analysis Female Lymph Nodes Neoplasm Grading business Carcinoma Endometrioid Follow-Up Studies |
| Zdroj: | International Journal of Gynecological Pathology. 37:17-21 |
| ISSN: | 0277-1691 |
| Popis: | The aim of this study was to examine the associations between microcystic, elongated, and fragmented (MELF) pattern and other prognostic factors and lymph node involvement, disease-free survival, and overall survival (OS) using a case-control group consisting of grade I-II endometrioid endometrial carcinoma (EEC) patients with/without lymph node involvement. The files of the patients were searched electronically for all hysterectomy specimens with a diagnosis of grade I-II EEC of the uterine body from January 1, 2008 to July 31, 2014. Lymph node involvement was detected in 27 patients who were histologically diagnosed with grade I-II EEC, and these patients made up the case group. Using a dependent random sampling method, 28 grade I-II EEC patients without lymph node involvement were selected. According to multivariate regression analysis, lymphovascular space invasion [odds ratio, 23.5; 95% confidence interval (CI), 2.4-223.5] and MELF pattern (odds ratio, 13.3; 95% CI, 1.4-121.8) were significant predictors of lymph node involvement. There was recurrence in 15.8% of cases that showed a MELF pattern and in 19.4% of those that did not (P=0.738). According to Kaplan-Meier analysis, the MELF pattern revealed no significant differences in disease-free survival (hazard ratio, 1.0; 95% CI, 0.1-36.5), whereas the effect on OS was significant (hazard ratio, 2.2; 95% CI, 1.3-4.2). The presence of MELF pattern was a substantial risk factor for detecting lymph node involvement in patients with grade I-II EEC. The MELF pattern may be important for identifying which patients need staging surgery, in addition to its effect on the OS. |
| Databáze: | OpenAIRE |
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