Age‐dependent effects of APOE ε4 in preclinical Alzheimer's disease

Autor:	Josiah K. Leong, Chun Chieh Fan, Ole A. Andreassen, Rahul S. Desikan, Gerard D. Schellenberg, John Kornak, Anders M. Dale, Jennifer S. Yokoyama, Lilah M. Besser, Bruce L. Miller, Walter A. Kukull, Howard J. Rosen, William P. Dillon, Ethan G. Geier, Luke W. Bonham, Christopher P. Hess
Rok vydání:	2016
Předmět:	0301 basic medicine Gerontology business.industry General Neuroscience Age dependent 3. Good health 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Medicine Neurology (clinical) Theology business Research Articles 030217 neurology & neurosurgery Research Article
Zdroj:	Annals of Clinical and Translational Neurology
ISSN:	2328-9503
Popis:	Objective The ε4 allele of apolipoprotein E (APOE) is the strongest known common genetic risk factor for Alzheimer's disease (AD) and alters age of onset in retrospective studies. Here, we longitudinally test the effects of APOE ε4 genotype and age during progression from normal cognition to AD. Methods Using data from 5381 cognitively normal older individuals and Cox proportional hazards models, we longitudinally tested the effects of APOE genotype on progression from normal cognition to mild cognitive impairment (MCI) or AD in four age strata (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ae74a4f612602bb79ec720706f70ef https://doi.org/10.1002/acn3.333 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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