Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration
| Autor: | Bach, Frances C, Poramba-Liyanage, Deepani W, Riemers, Frank M, Guicheux, Jerome, Camus, Anne, Iatridis, James C, Chan, Danny, Ito, Keita, Le Maitre, Christine L, Tryfonidou, Marianna A, Chirurgie, dCSCA RMSC-1, CS_Locomotion |
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| Přispěvatelé: | Utrecht University [Utrecht], RMeS - Regenerative Medicine of Bone Tissues (RMeS-REGOS), Université d'Angers (UA)-Regenerative Medicine and Skeleton (RMeS), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR Odontologie, Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR Odontologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Nantes Université - UFR Odontologie, PHU 4 OTONN [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Icahn School of Medicine at Mount Sinai [New York] (MSSM), The University of Hong Kong (HKU), Eindhoven University of Technology [Eindhoven] (TU/e), University Medical Center [Utrecht], Sheffield Hallam University, CAMUS, ANNE, Chirurgie, dCSCA RMSC-1, CS_Locomotion |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
[SDV]Life Sciences [q-bio] [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC] [SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology Notochordal cell [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] intervertebral disc – degeneration [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC] extracellularmatrix (ECM) low back pain [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system [SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis [SDV.BDD.MOR]Life Sciences [q-bio]/Development Biology/Morphogenesis [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology Cell Biology extracellular matrix (ECM) [SDV.BDD.MOR] Life Sciences [q-bio]/Development Biology/Morphogenesis [SDV] Life Sciences [q-bio] secretome [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system cell therapeutic potential [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] conditioned media (CM) Developmental Biology |
| Zdroj: | Frontiers in Cell and Developmental Biology Frontiers in Cell and Developmental Biology, 2022, 9, pp.780749. ⟨10.3389/fcell.2021.780749⟩ Frontiers in Cell and Developmental Biology, 9, 1. Frontiers Media S.A. |
| ISSN: | 2296-634X |
| Popis: | International audience; Chronic low back pain is the number one cause of years lived with disability. In about 40% of patients, chronic lower back pain is related to intervertebral disc (IVD) degeneration. The standard-of-care focuses on symptomatic relief, while surgery is the last resort. Emerging therapeutic strategies target the underlying cause of IVD degeneration and increasingly focus on the relatively overlooked notochordal cells (NCs). NCs are derived from the notochord and once the notochord regresses they remain in the core of the developing IVD, the nucleus pulposus. The large vacuolated NCs rapidly decline after birth and are replaced by the smaller nucleus pulposus cells with maturation, ageing, and degeneration. Here, we provide an update on the journey of NCs and discuss the cell markers and tools that can be used to study their fate and regenerative capacity. We review the therapeutic potential of NCs for the treatment of IVD-related lower back pain and outline important future directions in this area. Promising studies indicate that NCs and their secretome exerts regenerative effects, via increased proliferation, extracellular matrix production, and anti-inflammatory effects. Reports on NC-like cells derived from embryonic- or induced pluripotent-stem cells claim to have successfully generated NC-like cells but did not compare them with native NCs for phenotypic markers or in terms of their regenerative capacity. Altogether, this is an emerging and active field of research with exciting possibilities. NC-based studies demonstrate that cues from developmental biology can pave the path for future clinical therapies focused on regenerating the diseased IVD. |
| Databáze: | OpenAIRE |
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