Identification of LCN1 as a Potential Biomarker for Breast Cancer by Bioinformatic Analysis
| Autor: | Wei Wei, Luo Xueying, Jia Binghan, Rui Gao, Zhao Xiaoling, Liu Bao'er, Li Feng, Yuemei Yang, Yang Liping, Jinsong He |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
animal structures DNA Copy Number Variations endocrine system diseases Receptor ErbB-2 Somatic cell Cell Breast Neoplasms Biology 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine Breast cancer Immune system Downregulation and upregulation Databases Genetic Biomarkers Tumor Genetics medicine Humans Missense mutation skin and connective tissue diseases Molecular Biology Neoplasm Staging Cancer Cell Biology General Medicine Middle Aged medicine.disease Survival Analysis female genital diseases and pregnancy complications Perimenopause Gene Expression Regulation Neoplastic Postmenopause 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Mutation Cancer research Female Neoplasm Recurrence Local Lipocalin 1 |
| Zdroj: | DNA and Cell Biology. 38:1088-1099 |
| ISSN: | 1557-7430 1044-5498 |
| DOI: | 10.1089/dna.2019.4843 |
| Popis: | The biological functions of lipocalin-1 (LCN1) are involved in innate immune responses and act as a physiological scavenger of potentially harmful lipophilic molecules. However, the relevance of LCN1 with cancer is rarely concerned currently. The aim of this study is to address the relevance of LCN1 with BRCA by bioinformatics. In this study, we found that the expressions of LCN1 increased significantly in various cancerous tissues, including BRCA, compared with their adjacent normal tissues through the TIMER database. Furthermore, UALCAN database analysis showed that the expression of LCN1 increased gradually from stage 1 to stage 4 and was upregulated in BRCA patients with different races and subtypes compared with that in the normal. In addition, those patients with perimenopause and postmenopause status displayed higher LCN1 expression. Importantly, LCN1 genetic alterations, including copy number amplification, deep deletion, and missense mutation, could be found, and the alteration frequency showed difference in various invasive BRCA through cBioPortal database. Moreover, a positive correlation between LCN1 somatic copy number alterations and immune cell enrichments was revealed in basal like BRCA by GISTIC 2.0. Finally, analysis on prognostic value of LCN1 by Kaplan-Meier plotter showed that low LCN1 expression correlated with poor prognosis for relapse-free survival in all types of BRCA, overall survival in luminal B BRCA, distant metastasis free survival in human epithelial growth factor receptor-2 (HER2) positive BRCA, and postprogression survival (PPS) in luminal A BRCA. But high LCN1 expression also displayed poor prognosis for PPS in HER2 positive BRCA. The results together verified the significance of LCN1 in BRCA, suggesting that it may be a potential biomarker for BRCA diagnosis. |
| Databáze: | OpenAIRE |
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