Autor: |
Gretchen Tibbits, Abdelrhman Mohamed, Suzanne Gelston, Laure Flurin, Yash S. Raval, Kerryl E. Greenwood‐Quaintance, Robin Patel, Haluk Beyenal |
Rok vydání: |
2022 |
Předmět: |
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Zdroj: |
Biotechnology and bioengineeringREFERENCES. 120(1) |
ISSN: |
1097-0290 |
Popis: |
The activity of a hypochlorous acid-producing electrochemical bandage (e-bandage) in preventing methicillin-resistant Staphylococcus aureus infection (MRSA) infection and removing biofilms formed by MRSA was assessed using a porcine explant biofilm model. e-Bandages inhibited S. aureus infection (p = 0.029) after 12 h (h) of exposure and reduced 3-day biofilm viable cell counts after 6, 12, and 24 h exposures (p = 0.029). Needle-type microelectrodes were used to assess HOCl concentrations in explant tissue as a result of e-bandage treatment; toxicity associated with e-bandage treatment was evaluated. HOCl concentrations in infected and uninfected explant tissue varied between 30 and 80 µM, decreasing with increasing distance from the e-bandage. Eukaryotic cell viability was reduced by an average of 71% and 65% in fresh and day 3-old explants, respectively, when compared to explants exposed to nonpolarized e-bandages. HOCl e-bandages are a promising technology that can be further developed as an antibiotic-free treatment for wound biofilm infections. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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