Studies on the Role of Ca++ and Mg++ in Complement Fixation and Immune Hemolysis

Autor:	Lawrence Levine, Keith M. Cowan, Abraham G. Osler, Manfred M. Mayer
Rok vydání:	1953
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 71:359-366
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.71.5.359
Popis:	Summary By means of quantitative precipitin analyses, it has been shown that EDTA inhibits the capacity of specific precipitates to take up the combining component or components of C′ from fresh guinea pig and human sera. In accord with this finding based on weight determination, the hemolytic activity of C′ is not removed by specific precipitates in the presence of EDTA. Ca++ and Mg++, as well as Co++, reverse the inhibition of C′ fixation by EDTA. These results suggest the Ca++ and/or Mg++ are essential for C′ fixation.
Databáze:	OpenAIRE
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