Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations
| Autor: | Doris K. Wu, Gregg Duester, Kathleen E. Cullen, Kazuya Ono, Omid A. Zobeiri, Omar López Ramírez, James M. Keller, Andrianna I. Ayiotis, Sarath Vijayakumar, Charles C. Della Santina, Sherri M. Jones, Antonia González Garrido, Ruth Anne Eatock, Hui Ho Vanessa Chang |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Science Retinoic acid General Physics and Astronomy Tretinoin Biology General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences chemistry.chemical_compound Otolithic Membrane 0302 clinical medicine Tremor medicine otorhinolaryngologic diseases Animals Inner ear Evoked potential Saccule and Utricle lcsh:Science Evoked Potentials Otolith Vestibular system Mice Knockout Multidisciplinary Semicircular canal Gene Expression Regulation Developmental Retinal Dehydrogenase General Chemistry Retinoic Acid 4-Hydroxylase Vestibular Function Tests Cell biology Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure chemistry Vestibule Reflex lcsh:Q Female Osteopontin sense organs Vestibule Labyrinth Head 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| ISSN: | 2041-1723 |
| Popis: | Each vestibular sensory epithelium in the inner ear is divided morphologically and physiologically into two zones, called the striola and extrastriola in otolith organ maculae, and the central and peripheral zones in semicircular canal cristae. We found that formation of striolar/central zones during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)-mediated degradation of retinoic acid (RA). In Cyp26b1 conditional knockout mice, formation of striolar/central zones is compromised, such that they resemble extrastriolar/peripheral zones in multiple features. Mutants have deficient vestibular evoked potential (VsEP) responses to jerk stimuli, head tremor and deficits in balance beam tests that are consistent with abnormal vestibular input, but normal vestibulo-ocular reflexes and apparently normal motor performance during swimming. Thus, degradation of RA during embryogenesis is required for formation of highly specialized regions of the vestibular sensory epithelia with specific functions in detecting head motions. The coding of sensory inputs at the level of vestibular sensory organs is not well understood. In this study, the authors demonstrate that the formation of striolar/central zones during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)-mediated degradation of retinoic acid and show that Cyp26b1 cKO mice have abnormal vestibular evoked potentials and balance beam performance, but normal vestibular-ocular reflexes. |
| Databáze: | OpenAIRE |
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