[Correlation between peripheral blood CD4+CD25high CD127low regulatory T cell and clinical characteristics of patients with non-Hodgkin's lymphoma]
| Autor: | Xiaofei Sun, Tong Yu Lin, Zhong Jun Xia, Yi Xia, Hui Lin, Hui Qiang Huang, Jia Yu Ling, Zi Jun Zhen |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Alcohol Drinking Regulatory T cell chemical and pharmacologic phenomena Lymphoma T-Cell Gastroenterology T-Lymphocytes Regulatory Interleukin-7 Receptor alpha Subunit Young Adult Sex Factors hemic and lymphatic diseases Internal medicine medicine Humans IL-2 receptor Interleukin-7 receptor Child Aged Aged 80 and over biology business.industry Lymphoma Non-Hodgkin Smoking Interleukin-2 Receptor alpha Subunit Cancer Hepatitis B Middle Aged medicine.disease Non-Hodgkin's lymphoma Lymphoma medicine.anatomical_structure Oncology Child Preschool Immunology CD4 Antigens biology.protein Female Lymphoma Large B-Cell Diffuse Antibody business |
| Zdroj: | Ai zheng = Aizheng = Chinese journal of cancer. 28(11) |
| Popis: | BACKGROUND AND OBJECTIVE Non-Hodgkin's lymphoma (NHL) is a malignant disease originating from immune system. Studies of the possible relationship between NHL and immune suppression status are of great concern. Regulatory T cell (Treg) is a subtype of T cells that exert an immunosuppressive function. However, the relationship between Treg and lymphoma is controversial. The study was to detect peripheral blood levels of Treg in patients with NHL and healthy adults, and to explore the possible relationship between peripheral blood Treg level and NHL. METHODS By using flow cytometry with surface staining fluorochrome-conjugated antibodies for CD4, CD25, CD127, the percentages of CD4+CD25highCD127low Treg in peripheral blood of 31 healthy adults and 99 newly diagnosed NHL patients, hospitalized in Sun Yet-sen University Cancer Center from December 2006 to March 2008, were detected and analyzed. RESULTS The average peripheral blood CD4+CD25highCD127low Treg levels were 8.07+/-1.90 and 11.20+/-4.40 in healthy adults and newly diagnosed NHL patients, respectively. The difference of peripheral blood Treg levels between them was statistically significant (P |
| Databáze: | OpenAIRE |
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