New insights into macrophage heterogeneity in rheumatoid arthritis
| Autor: | Nicole Hannemann, Florence Apparailly, Gabriel Courties |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Inflammation
Monocytes Arthritis Rheumatoid Pathogenesis 03 medical and health sciences 0302 clinical medicine Rheumatology Synovial joint medicine Animals Humans Macrophage 030212 general & internal medicine 030203 arthritis & rheumatology Autoimmune disease business.industry Macrophages Cartilage Synovial Membrane medicine.disease Phenotype medicine.anatomical_structure Rheumatoid arthritis Immunology medicine.symptom business |
| Zdroj: | Joint Bone Spine. 88:105091 |
| ISSN: | 1297-319X |
| DOI: | 10.1016/j.jbspin.2020.105091 |
| Popis: | Rheumatoid arthritis (RA) is a prototypic autoimmune disease that primarily affects joints. Clinical studies and animal models evidenced that mononuclear phagocytes including monocytes and macrophages are crucial to RA pathogenesis, contributing to inflammation and destruction of cartilage and bone. The last decade of research has tremendously changed our view on the origin of tissue-resident macrophages. In light of the recent publications that reveal important phenotypic and functional heterogeneity among macrophages, it is of paramount importance to identify the synovial macrophage subsets that might amplify the inflammatory response or promote the restoration of tissue homeostasis. In this review, we highlight latest studies applying single-cell RNA sequencing that provide deeper insights in macrophage subsets and their putative functions within both human and mouse synovial joint tissue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect