Similarities and differences in lipidomics profiles among healthy monozygotic twin pairs
| Autor: | J. van der Greef, Ivana Bobeldijk-Pastorova, Jacqueline J. Meulman, Meike Bartels, Dorret I. Boomsma, Harmen H.M. Draisma, Theo H. Reijmers, Thomas Hankemeier, Raymond Ramaker, G.F. van Burk |
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| Přispěvatelé: | Biological Psychology, EMGO+ - Mental Health, Pediatric surgery, EMGO - Mental health, TNO Kwaliteit van Leven |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
Netherlands Twin Register (NTR) Heredity Monozygotic twin medicine.disease_cause 01 natural sciences Biochemistry Priority journal Genetics 0303 health sciences medicine.diagnostic_test Environmental exposure Phenotype Lipids 3. Good health C-Reactive Protein Molecular Medicine Female Monozygotic twins Biotechnology Human Adult Spectrometry Mass Electrospray Ionization Adolescent Liquid chromatography Context (language use) Major clinical study Biology Article Health status 03 medical and health sciences Lipidomics medicine Metabolome Humans Molecular Biology Analytical research 030304 developmental biology Mass spectrometry 010401 analytical chemistry Twins Monozygotic Lipid blood level 0104 chemical sciences Lipid profile Controlled study Chromatography Liquid |
| Zdroj: | OMICS: A Journal of Integrative Biology, 12(1), 17-31. Mary Ann Liebert Inc. OMICS A Journal of Integrative Biology, 1, 12, 17-31 Draisma, H H M, Reijmers, T H, Bobeldijk-Pastorova, I, Meulman, J J, van Burk, G F, Bartels, M, Ramaker, R, van der Greef, J, Boomsma, D I & Hankemeier, T 2008, ' Similarities and differences in lipidomics profiles among healthy monozygotic twin pairs. ', OMICS: A Journal of Integrative Biology, vol. 12, no. 1, pp. 17-31 . https://doi.org/10.1089/omi.2007.0048 |
| ISSN: | 1536-2310 |
| DOI: | 10.1089/omi.2007.0048 |
| Popis: | Differences in genetic background and/or environmental exposure among individuals are expected to give rise to differences in measurable characteristics, or phenotypes. Consequently, genetic resemblance and similarities in environment should manifest as similarities in phenotypes. The metabolome reflects many of the system properties, and is therefore an important part of the phenotype. Nevertheless, it has not yet been examined to what extent individuals sharing part of their genome and/or environment indeed have similar metabolomes. Here we present the results of hierarchical clustering of blood plasma lipid profile data obtained by liquid chromatographymass spectrometry from 23 healthy, 18-year-old twin pairs, of which 21 pairs were monozygotic, and 8 of their siblings. For 13 monozygotic twin pairs, within-pair similarities in relative concentrations of the detected lipids were indeed larger than the similarities with any other study participant. We demonstrate such high coclustering to be unexpected on basis of chance. The similarities between dizygotic twins and between nontwin siblings, as well as between nonfamilial participants, were less pronounced. In a number of twin pairs, within-pair dissimilarity of lipid profiles positively correlated with increased blood plasma concentrations of C-reactive protein in one twin. In conclusion, this study demonstrates that in healthy individuals, the individual genetic background contributes to the blood plasma lipid profile. Furthermore, lipid profiling may prove useful in monitoring health status, for example, in the context of personalized medicine. © 2008 Mary Ann Liebert, Inc. Chemicals / CAS: C-Reactive Protein, 9007-41-4; Lipids |
| Databáze: | OpenAIRE |
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