Neonatal sepsis is mediated by maternal fever in labour epidural analgesia
| Autor: | E. M. I. Dorssers, R. M. J. Moonen, Bjorn Winkens, Frans J.M.E. Roumen, M. M. L. H. Wassen, Marco A. E. Marcus |
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| Přispěvatelé: | FHML Methodologie & Statistiek, RS: CAPHRI School for Public Health and Primary Care, Obstetrie & Gynaecologie, Kindergeneeskunde, Anesthesiologie, RS: CAPHRI - Design and analysis of studies in health sciences, RS: MHeNs - R3 - Neuroscience |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Fever Neonatal sepsis Obstetrics business.industry Incidence (epidemiology) Infant Newborn Maternal Fever Obstetrics and Gynecology medicine.disease Analgesia Epidural Pregnancy Complications Pregnancy Sepsis Positive blood culture medicine Humans Female Risk factor business Netherlands Retrospective Studies Intrapartum Fever |
| Zdroj: | Journal of Obstetrics and Gynaecology, 34(8), 679-683. Informa Healthcare |
| ISSN: | 0144-3615 |
| Popis: | Women delivering with EA (EA group) were matched on parity with 453 women with deliveries without EA (non-EA group). Significantly more neonates born in the EA-group had fever ≥ 38.0°C (11.6% vs 1.8%, p < 0.001) at birth. The overall incidence of neonatal sepsis, based on clinical symptoms and defined as proven (by a positive blood culture) or suspected (no positive blood culture), was significantly higher in the EA group (6.0% vs 2.2%; p = 0.002), but the incidence of proven neonatal sepsis alone was not (0.4% vs 0%; p = 0.250). EA turned out to be an independent risk factor for neonatal sepsis (adjusted OR 2.43, 95% CI 1.15-5.13; p = 0.020). However, in the EA group as well as the non-EA group, the incidence of neonatal sepsis was significantly higher in mothers with intrapartum fever compared with afebrile mothers (11.0% vs 2.9% in the EA group; p = 0.004; 8.2% vs 1.3% in the non-EA group; p = 0.006). Therefore we conclude, that the positive association between neonatal sepsis and labour EA is possibly mediated by maternal intrapartum fever. |
| Databáze: | OpenAIRE |
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