Prognostic significance of a morphometric study of lymph node biopsies in chronic lymphocytic leukaemia
| Autor: | B. Guigui, L. Nonnenmacher, M. Raphael, J. L. Binet, S. Boisnic |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Lymphocytic leukaemia medicine.diagnostic_test business.industry Biopsy Chronic lymphocytic leukemia Lymph node biopsy Hematology Prognosis medicine.disease Leukemia Lymphoid Lymphoma medicine.anatomical_structure Skewness Chronic Disease Humans Medicine Lymph Nodes Stage (cooking) business Lymph node Follow-Up Studies Neoplasm Staging |
| Zdroj: | Scandinavian Journal of Haematology. 37:371-379 |
| ISSN: | 0036-553X |
| Popis: | In 18 chronic lymphocytic leukaemia (CLL) and 2 diffuse, well-differentiated lymphoma (DWDL) lymph node biopsies, morphometric results analysing nuclear area distribution curves by the skewness coefficient were compared to histological findings, clinical stage and survival. Lymphocytic proliferation was subclassified according to the number and the distribution of large lymphoid cells. All cases with a component of large lymphoid cells had a right deviation of the nuclear area distribution curve and a positive value of the skewness coefficient in contrast to those where lymphocytic proliferation was monomorphous. Good correlation was observed between histological findings, morphometric analysis and survival: most patients with a right deviation of nuclear area distribution curve and positive skewness coefficient are clinically stage C, or died within 2-44 months, in contrast to patients with a symmetric distribution of nuclear area curve who are clinically stage A or B and still alive. The results indicate that in CCL and DWDL the lymph node biopsy with quantitative analysis has prognostic significance. |
| Databáze: | OpenAIRE |
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