Undifferentiated Embryonal Sarcoma of the Liver in Children Versus Adults: A National Cancer Database Analysis

Autor:	Ioannis A. Ziogas, Harold N. Lovvorn, Sophoclis P. Alexopoulos, Christina E. Bailey, Irving J. Zamora
Rok vydání:	2021
Předmět:	hepatic sarcoma Cancer Research medicine.medical_specialty medicine.medical_treatment Article Metastasis liver cancer 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Undifferentiated (Embryonal) Sarcoma Risk of mortality RC254-282 Chemotherapy business.industry Proportional hazards model Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cancer medicine.disease liver sarcoma embryonal sarcoma humanities body regions Oncology National Cancer Database 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Embryonal rhabdomyosarcoma business Liver cancer
Zdroj:	Cancers Volume 13 Issue 12 Cancers, Vol 13, Iss 2918, p 2918 (2021)
ISSN:	2072-6694
Popis:	This study evaluates the clinicopathological characteristics and outcomes of children vs. adults with undifferentiated embryonal sarcoma of the liver (UESL). A retrospective analysis of 82 children (< 18 years) and 41 adults (≥18 years) with UESL registered in the National Cancer Database between 2004–2015 was conducted. No between-group differences were observed regarding tumor size, metastasis, surgical treatment, margin status, and radiation. Children received chemotherapy more often than adults (92.7% vs. 65.9% p < 0.001). Children demonstrated superior overall survival vs. adults (log-rank, p < 0.001) with 5-year rates of 84.4% vs. 48.2%, respectively. In multivariable Cox regression for all patients, adults demonstrated an increased risk of mortality compared to children (p < 0.001), while metastasis was associated with an increased (p = 0.02) and surgical treatment with a decreased (p = 0.001) risk of mortality. In multivariable Cox regression for surgically-treated patients, adulthood (p = 0.004) and margin-positive resection (p = 0.03) were independently associated with an increased risk of mortality. Multimodal treatment including complete surgical resection and chemotherapy results in long-term survival in most children with UESL. However, adults with UESL have poorer long-term survival that may reflect differences in disease biology and an opportunity to further refine currently available treatment schemas.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39e5a450559eb6ab2d11e4f02c8ea35 https://pubmed.ncbi.nlm.nih.gov/34208030 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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