Changes on hemostatic parameters induced by 17β-estradiol, ethinylestradiol, and the 17β-aminoestrogen pentolame in the male Wistar rat
| Autor: | Cristina Lemini, Aurora García-Manzano, José González-Llaven, Ruth Jaimez, Consuelo Rubio-Póo, Yanira Franco, Ma. Estela Avila |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Clinical Biochemistry Thrombin time Ethinyl Estradiol Fibrinogen Biochemistry Hemostatics Endocrinology Bleeding time Ethinylestradiol Internal medicine medicine Animals Estrenes Rats Wistar Molecular Biology Pharmacology Diminution Prothrombin time Estradiol Molecular Structure medicine.diagnostic_test Chemistry Organic Chemistry Amino Alcohols Rats Hemostasis Blood Coagulation Tests medicine.drug Partial thromboplastin time |
| Zdroj: | Steroids. 67:1129-1135 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/s0039-128x(02)00067-3 |
| Popis: | Oral contraceptives containing estrogens increases the incidence of thromboembolic events. In contrast, administration of 17beta-aminoestrogens prolonged blood clotting time (BCT) in rodents. We studied the effect of estradiol (E(2)), ethinylestradiol (EE) and pentolame on some screening hemostatic tests. BCT was evaluated 24, 48, 72 and 96 h post-treatment. Rats received subcutaneously (s.c.) for five consecutive days E(2) (0.1-1000 microg), EE (1-1000 microg), pentolame (0.1-1000 microg), or vehicle (propyleneglycol 0.3 ml). At 48 h post-treatment E(2) (1000 microg) diminished BCT (32%, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect