Unusual side-effects due to clobazam: a case report with genetic study of CYP2C19
| Autor: | Annio Posar, Simonetta Sangiorgi, P. Giovanardi-Rossi, Antonia Parmeggiani |
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| Přispěvatelé: | Antonia Parmeggiani, Annio Posar, Simonetta Sangiorgi, Paola Giovanardi-Rossi |
| Rok vydání: | 2004 |
| Předmět: |
Drug
Clobazam Metabolite media_common.quotation_subject Subcontinuous EEG Paroxysmal Abnormalities CYP2C19 Pharmacology medicine.disease_cause Mixed Function Oxygenases Epilepsy chemistry.chemical_compound Benzodiazepines Side-effect Developmental Neuroscience medicine Humans Child media_common Mutation Benzodiazepine business.industry Electroencephalography General Medicine Plasma levels Enuresis medicine.disease Dyssomnias Cytochrome P-450 CYP2C19 chemistry High plasma Pediatrics Perinatology and Child Health Anticonvulsants Female Neurology (clinical) Aryl Hydrocarbon Hydroxylases business medicine.drug |
| Zdroj: | Braindevelopment. 26(1) |
| ISSN: | 0387-7604 |
| Popis: | We describe the case of a 10-year-old girl with two epileptic seizures and subcontinuous spike-waves during sleep, who presented unusual side-effects related to clobazam (CLB) monotherapy. High plasma levels of N-desmethyl-clobazam (N-CLB), the major metabolite of CLB were detected. The patient and her parents underwent molecular analysis of the CYP2C19 gene, which may be implicated in the metabolism of this drug. Our patient presents one copy of the most common mutation (CYP2C19*2) affecting the activity of the isoenzyme and probably another rare or private mutation. CLB and N-CLB plasma level dosages and molecular analysis may be useful when a poor metabolic condition is suspected. |
| Databáze: | OpenAIRE |
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