Coating carbon nanotubes with a polystyrene-based polymer protects against pulmonary toxicity
| Autor: | Ari Setyan, Lyes Tabet, Jorge Boczkowski, Michel J. Rossi, Angélique Simon-Deckers, Cyrill Bussy, Sophie Lanone |
|---|---|
| Přispěvatelé: | Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, Department of Environmental Toxicology, University of California, Institut universitaire romand de Santé au Travail (Institute for Work and Health), Université de Genève (UNIGE)-Université de Lausanne (UNIL), Laboratory of Atmospheric Chemistry [Paul Scherrer Institute] (LAC), Paul Scherrer Institute (PSI), Service de pneumologie et pathologie professionnelle, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor, Pneumologie et Pathologie Professionnelle, CHI Créteil, Lyes Tabet was a recipient of a joint grant from ADEME (Agence de l'Environnement et de la Maitrîse de l'Énergie) and ARKEMA., BMC, Ed., Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), University of California (UC), Université de Lausanne = University of Lausanne (UNIL)-Université de Genève = University of Geneva (UNIGE) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Pulmonary toxicity Health Toxicology and Mutagenesis Biocompatible Materials 02 engineering and technology Toxicology MESH: Occupational Exposure law.invention chemistry.chemical_compound Mice Coating MESH: Biocompatible Materials law MESH: Animals Cytotoxicity Lung chemistry.chemical_classification 0303 health sciences Inhalation Exposure Mice Inbred BALB C MESH: Oxidative Stress MESH: Polystyrenes General Medicine Polymer 021001 nanoscience & nanotechnology Occupational Diseases MESH: Cell Survival Toxicity MESH: Nanotubes Carbon MESH: Microscopy Electron Transmission MESH: Inhalation Exposure 0210 nano-technology MESH: Occupational Diseases Materials science Cell Survival Acute Lung Injury lcsh:Industrial hygiene. Industrial welfare MESH: Mice Inbred BALB C Nanotechnology Carbon nanotube engineering.material 03 medical and health sciences Microscopy Electron Transmission In vivo lcsh:RA1190-1270 Occupational Exposure Intubation Intratracheal Animals MESH: Lung Nanotubes Carbon Polystyrenes MESH: Mice 030304 developmental biology lcsh:Toxicology. Poisons MESH: Intubation Intratracheal Research Macrophages MESH: Acute Lung Injury MESH: Macrophages MESH: Male Oxidative Stress chemistry [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie engineering Biophysics [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Polystyrene lcsh:HD7260-7780.8 |
| Zdroj: | Particle and Fibre Toxicology Particle and Fibre Toxicology, BioMed Central, 2011, 8 (1), pp.3. ⟨10.1186/1743-8977-8-3⟩ Particle and Fibre Toxicology, Vol 8, Iss 1, p 3 (2011) Particle and Fibre Toxicology, vol. 8, no. 3, pp. 1-13 Tabet, L, Bussy, C, Setyan, A, Simon-Deckers, A, Rossi, M J, Boczkowski, J & Lanone, S 2011, ' Coating carbon nanotubes with a polystyrene-based polymer protects against pulmonary toxicity ', Particle and Fibre Toxicology, vol. 8, 3 . https://doi.org/10.1186/1743-8977-8-3 Particle and Fibre Toxicology, 2011, 8 (1), pp.3. ⟨10.1186/1743-8977-8-3⟩ |
| ISSN: | 1743-8977 |
| DOI: | 10.1186/1743-8977-8-3⟩ |
| Popis: | Background carbon nanotubes (CNT) can have adverse effects on health. Therefore, minimizing the risk associated with CNT exposure is of crucial importance. The aim of this work was to evaluate if coating multi-walled CNT (MWCNT) with polymers could modify their toxicity, thus representing a useful strategy to decrease adverse health effects of CNT. We used industrially-produced MWCNT uncoated (NT1) or coated (50/50 wt%) with acid-based (NT2) or polystyrene-based (NT3) polymer, and exposed murine macrophages (RAW 264.7 cell line) or Balb/c mice by intratracheal administration. Biological experiments were performed both in vitro and in vivo, examining time- and dose-dependent effects of CNT, in terms of cytotoxicity, expression of genes and proteins related to oxidative stress, inflammation and tissue remodeling, cell and lung tissue morphology (optical and transmission electron microscopy), and bronchoalveolar lavage fluid content analysis. Results extensive physico-chemical characterization of MWCNT was performed, and showed, although similar dimensions for the 3 MWCNT, a much smaller specific surface area for NT2 and NT3 as compared to NT1 (54.1, 34 and 227.54 m2/g respectively), along with different surface characteristics. MWCNT-induced cytotoxicity, oxidative stress, and inflammation were increased by acid-based and decreased by polystyrene-based polymer coating both in vitro in murine macrophages and in vivo in lung of mice monitored for 6 months. Conclusions these results demonstrate that coating CNT with polymers, without affecting their intrinsic structure, may constitute a useful strategy for decreasing CNT toxicity, and may hold promise for improving occupational safety and that of general the user. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink