Association of Genetic Factors and Gene–Environment Interactions With Risk of Developing Posttraumatic Stress Disorder in a Case–Control Study
| Autor: | Thomas K.S. Wong, Yangjing Bai, Jiping Li, Yali Tian, Lorna Guse, Hui Liu, Xiaolian Jiang |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Genotype Affect (psychology) Stress Disorders Post-Traumatic Risk Factors mental disorders Earthquakes medicine Humans Gene–environment interaction Psychiatry Association (psychology) Gene Serotonin transporter Serotonin Plasma Membrane Transport Proteins Polymorphism Genetic Research and Theory biology Receptors Dopamine D2 Case-control study Case-Control Studies 5-HTTLPR biology.protein Female Gene-Environment Interaction Psychology Clinical psychology |
| Zdroj: | Biological Research For Nursing. 17:364-372 |
| ISSN: | 1552-4175 1099-8004 |
| DOI: | 10.1177/1099800415588362 |
| Popis: | Background: The dopamine receptor D2 ( DRD2) and serotonin transporter ( 5-HTT) genes are associated with posttraumatic stress disorder (PTSD). However, it remains largely unknown whether these genes interact with environmental factors to affect the development of PTSD. Purpose: The purpose of this study was to examine the associations of gene polymorphisms and gene–environment interactions with the risk of developing PTSD among adolescent earthquake survivors. Method: A total of 183 adolescent survivors from an earthquake-stricken area participated in this study. Measures included a questionnaire about demographic characteristics and earthquake exposure, the PTSD Checklist–Civilian Version and the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, fourth edition disorders. Genotypes were analyzed by using the polymerase chain reaction–based restriction fragment length polymorphism. Results: The 5-HTTLPR and 5-HTTVNTR polymorphisms and earthquake exposure had statistically significant positive effects on PTSD. The interaction effects of 5-HTTLPR × Earthquake Exposure and 5-HTTVNTR × Earthquake Exposure were statistically significant. Conclusion: The development of PTSD is the result not only of a genetic effect and environmental factors but also of the interactive effect between gene and environment. |
| Databáze: | OpenAIRE |
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