Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin
| Autor: | Hsi Lin Chiu, Ming-Jai Su, Cheng Fung Chuang, Yi Chun Weng, Yen-Chu Lin, Tzong-Cherng Chi, Yueh-Hsiung Kuo, Sung Ting Chuang |
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| Rok vydání: | 2012 |
| Předmět: |
Article Subject
business.industry food and beverages lcsh:Other systems of medicine Pharmacology Resveratrol lcsh:RZ201-999 medicine.disease Esterase Proinflammatory cytokine Streptozocin chemistry.chemical_compound Complementary and alternative medicine chemistry In vivo Diabetes mellitus Amide Caffeic acid Medicine business Research Article |
| Zdroj: | Evidence-Based Complementary and Alternative Medicine, Vol 2012 (2012) Evidence-based Complementary and Alternative Medicine : eCAM |
| ISSN: | 1741-4288 1741-427X |
| DOI: | 10.1155/2012/984780 |
| Popis: | Caffeic acid phenyl ester is distributed wildly in nature and has antidiabetic and cardiovascular protective effects. However, rapid decomposition by esterase leads to its low bioavailability in vivo. In this study, chronic metabolic and cardiovascular effects of oral caffeic acid phenylethyl amide, whose structure is similar to caffeic acid phenyl ester and resveratrol, were investigated in ICR mice. We found that caffeic acid phenylethyl amide protected against diet or streptozocin-induced metabolic changes increased coronary flow and decreased infarct size after global ischemia-reperfusion in Langendorff perfused heart. Further study indicated that at least two pathways might be involved in such beneficial effects: the induction of the antioxidant protein MnSOD and the decrease of the proinflammatory cytokine TNFαand NFκB in the liver. However, the detailed mechanisms of caffeic acid phenylethyl amide need further studies. In summary, this study demonstrated the protective potential of chronic treatment of caffeic acid phenylethyl amide against the metabolic consequences in diabetes mellitus. |
| Databáze: | OpenAIRE |
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