Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) Modulates TCD4+ and TCD8+ Cell Profile of Doxorubicin-Induced Immuno-Suppressed Rats
| Autor: | Denny Satria, Reny Haryani, Safriana Safriana, Mustafa Ridwan Lubis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Blood level
food.ingredient Side effect medicine.medical_treatment Cell Ethanolic Extract lcsh:Medicine 030209 endocrinology & metabolism Picria fel-terrae Lour Body weight Herbal Medicine in Pharmaceutical and Clinical Sciences 03 medical and health sciences TCD4 0302 clinical medicine food TCD8+ TCD8 medicine Sprague dawley rats Doxorubicin 030212 general & internal medicine Saline Traditional medicine business.industry lcsh:R General Medicine TCD4+ medicine.anatomical_structure Herb Immunomodulator business medicine.drug |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences Open Access Macedonian Journal of Medical Sciences, Vol 7, Iss 22 (2019) Open Access Macedonian Journal of Medical Sciences; Vol. 7 No. 22 (2019): Nov 30 (Herbal Medicine in Pharmaceutical and Clinical Sciences); 3774-3776 |
| ISSN: | 1857-9655 |
| Popis: | AIM: To evaluate the immunomodulatory effects of ethanolic extract of herb pugun tanoh on TCD4 and TCD8 cells in Doxorubicin-induced rats. METHODS: Fifteen male Sprague Dawley rats were divided into five groups consisting of six rats each as follows: Group 1, DOX-treated rats (4.67 mg/kg BW body weight on day 1 and 4) and were administered normal saline 0.9% orally once daily for 7 consecutive days, Group 2, receiving Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) of dose 150 mg/kg BW orally, Group 3, receiving dose Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) 300 mg/kg BW orally. The rats of group 2-3 were intramuscularly administered with doxorubicin at a dose of 4.67 mg/kg BW at the days 1-4 to suppress immune functions. RESULTS: Treatment of 300 mg/kg BW of Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) succeeded in reducing side effect doxorubicin based on increasing the TCD4+ and TCD8+ blood level. CONCLUSION: Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) could increase the level of TCD4+ and TCD8+ in rats which induced by doxorubicin. |
| Databáze: | OpenAIRE |
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