ACTH-(1-24) and hemorrhagic shock: Preliminary clinical results
| Autor: | Piermaria Pensa, B. Bentini, B. Biagi, G. Noera, C. Curcio, P. Guelfi |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
endocrine system
business.industry Hemodynamics Neuropeptide Endogeny Shock Hemorrhagic Emergency Nursing Pharmacology Pathophysiology Anesthesia Shock (circulatory) Hypovolemia Hemorrhagic shock Emergency Medicine medicine Cosyntropin Humans Endorphins medicine.symptom Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists Endogenous opioid |
| Zdroj: | Resuscitation. 18:145-147 |
| ISSN: | 0300-9572 |
| DOI: | 10.1016/0300-9572(89)90010-5 |
| Popis: | Many recent reports indicate that in several models of shock there is a massive activation of endogenous opioid systems and that endorphins play a key role in the pathophysiology of circulatory shock [1,2]. In recent years, on the basis of growing experimental support, it has been suggested that some neuropeptides (ACTH-MSH peptides, TRH etc.) may play the role of endogenous ‘physiological’ antagonists of opioids [3]. We report here that ACTH-(1 241 has a therapeutic effect in hemorrhagic shock in man. |
| Databáze: | OpenAIRE |
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