123I-FP-CIT in progressive supranuclear palsy and in Parkinsonʼs disease: a SPECT semiquantitative study

Autor: Livia Brusa, Paolo Stanzione, Luca Filippi, Mariangela Pierantozzi, Orazio Schillaci, Carlo Manni, Roberta Danieli
Rok vydání: 2006
Předmět:
Male
Pathology
medicine.medical_specialty
Parkinson's disease
Single photon emission computerized tomography
Sensitivity and Specificity
Severity of Illness Index
Progressive supranuclear palsy
Diagnosis
Differential
Computer-Assisted
Progressive
Settore MED/36 - Diagnostica per Immagini e Radioterapia
123I-FP-CIT
Diagnosis
Image Interpretation
Computer-Assisted
Severity of illness
medicine
Supranuclear Palsy
Humans
Radiology
Nuclear Medicine and imaging
Tomography
Image Interpretation
Aged
Tomography
Emission-Computed
Single-Photon
business.industry
Reproducibility of Results
Parkinson Disease
General Medicine
Middle Aged
medicine.disease
eye diseases
Supranuclear palsy
Differential
Female
Emission-Computed
Supranuclear Palsy
Progressive
Radiology
Radiopharmaceuticals
business
Tropanes
Semi quantitative
Single-Photon
Zdroj: Nuclear Medicine Communications. 27:381-386
ISSN: 0143-3636
DOI: 10.1097/01.mnm.0000202858.45522.df
Popis: It is still debated whether or not I-FP-CIT single photon emission computerized tomography (SPECT) is able to differentiate between Parkinson's disease and progressive supranuclear palsy (PSP). Our aim was to use SPECT semiquantitative analysis to assess the capacity of I-FP-CIT to characterize Parkinson's disease versus PSP.Twenty-one Parkinson's disease patients, 15 disease duration- and age-matched PSP patients and 20 age-matched healthy controls were included in this study. SPECT imaging was always performed at 4 h post-injection. The ratios of striatal (S) to non-specific occipital (O) binding for the entire striatum (S/O), caudate nuclei (C/O), putamina (P/O) were calculated in both the basal ganglia. The asymmetric index (AI) for the whole striatum was also calculated for Parkinson's disease and PSP.Compared to healthy controls, S/O, C/O and P/O were significantly reduced (P0.001) both in Parkinson's disease (-46%, -43%, -49%, contralaterally to the most affected side; -41%, -37%, -41%, ipsilaterally) and in PSP (-58%, -57%, -59%, contralaterally; -58%, -57%, -59%, ipsilaterally). S/O, C/O and P/O ratio values were significantly (P0.001) lower in PSP patients when compared to Parkinson's disease group. The asymmetric index (AI) was significantly higher (P0.001) in Parkinson's disease than in PSP (AI: 23.6%+/-15.07% vs. 9.66%+/-5.83), but with an overlap between the two groups.Our results confirm that I-FP-CIT SPECT is clinically useful for detecting nigrostriatal degeneration both in Parkinson's disease and PSP. Moreover, in our series, semiquantitative analysis using I-FP-CIT SPECT allowed Parkinson's disease and PSP to be discriminated because PSP patients presented a more severe and symmetric dopamine transporter loss, and the results for S/O were more accurate.
Databáze: OpenAIRE
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