Higher docosahexaenoic acid, lower arachidonic acid and reduced lipid tolerance with high doses of a lipid emulsion containing 15% fish oil: a randomized clinical trial

Autor: Maria Paola Bellagamba, Chiara Biagetti, Adriana Pompilio, Paola Cogo, Rita D'Ascenzo, Virgilio P. Carnielli, Paolo Marchionni, Sara Savini
Rok vydání: 2013
Předmět:
Lipid tolerance
Male
Parenteral Nutrition
Fat Emulsions
Critical Care and Intensive Care Medicine
Soybean oil
chemistry.chemical_compound
Medicine
Birth Weight
Food science
Phospholipids
chemistry.chemical_classification
Omega-3
Nutrition and Dietetics
Arachidonic Acid
alpha-Linolenic acid
Medicine (all)
Fatty Acids
Fish oil
Eicosapentaenoic acid
Docosahexaenoic acid
Treatment Outcome
Biochemistry
Eicosapentaenoic Acid
Arachidonic acid
Emulsions
Female
Intravenous
Infant
Premature
Fat Emulsions
Intravenous
food.ingredient
Docosahexaenoic Acids
Linoleic acid
Parenteral nutrition
Preterm infants
Bilirubin
Fatty Acids
Omega-3
Fish Oils
Humans
Infant
Newborn
Olive Oil
Parenteral Nutrition Solutions
Plant Oils
Soybean Oil
Triglycerides
food
Premature
business.industry
Fatty acid
Infant
Newborn
chemistry
business
Zdroj: Clinical nutrition (Edinburgh, Scotland). 33(6)
ISSN: 1532-1983
Popis: Summary Background & aims Lipid emulsions containing fish oil, as source of long chain omega 3 fatty acids, have recently became available for parenteral nutrition in infants, but scanty data exist in extremely low birth weight preterms. The objective of this study was to compare plasma fatty acids and lipid tolerance in preterm infants receiving different doses of a 15% fish oil vs. a soybean oil based lipid emulsion. Methods Preterm infants (birth weight 500–1249 g) were randomized to receive parenteral nutrition with MOSF (30% Medium-chain triglycerides, 25% Olive oil, 30% Soybean oil, 15% Fish oil) or S (S, 100% Soybean oil) both at two levels of fat intake: 2.5 or 3.5 g kg −1 d −1 , named 2.5Fat and 3.5Fat respectively. Plasma lipid classes and their fatty acid composition were determined on postnatal day 7 and 14 by gas chromatography together with routine biochemistry. Results We studied 80 infants. MOSF infants had significantly higher plasma phospholipid Docosahexaenoic acid and Eicosapentaenoic and lower Arachidonic acid. Plasma phospholipids, triglycerides and free cholesterol were all significantly higher in the MOSF-3.5Fat group, while cholesterol esters were lower with MOSF than with S. The area under the curve of total bilirubin was significantly lower with MOSF than with S. Conclusions The use of a lipid emulsion with 15% FO resulted in marked changes of plasma long-chain fatty acids. Whether the benefits of increasing Docosahexaenoic acid outweigh the potential negative effect of reduced Arachidonic acid should be further studied. MOSF patients exhibited reduced lipid tolerance at 3.5 g kg −1 d −1 fat intake. The trial was conducted between January 2008 and December 2012 so we had not registered it in a public trials registry as it is now required for trials that started after July 2008.
Databáze: OpenAIRE
Externí odkaz: