Admission Hyperglycemia Is an Independent Predictor of Acute Kidney Injury in Patients With Acute Myocardial Infarction
| Autor: | Michio Nakanishi, Noriaki Moriyama, Yoichi Goto, Toshihisa Anzai, Satoshi Yasuda, Satoshi Honda, Toshiyuki Nagai, Masashi Fujino, Yasuhide Asaumi, Masaharu Ishihara, Hisao Ogawa, Takafumi Yamane, Tadayoshi Miyagi, Teruo Noguchi, Tetsuo Arakawa, Reiko Fujiwara, Leon Kumasaka, Tomoaki Kanaya, Kengo Kusano |
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| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Myocardial Infarction urologic and male genital diseases chemistry.chemical_compound Internal medicine medicine Humans Registries Myocardial infarction Aged Retrospective Studies Aged 80 and over Creatinine business.industry Acute kidney injury Electrocardiography in myocardial infarction Retrospective cohort study General Medicine Odds ratio Acute Kidney Injury Middle Aged medicine.disease female genital diseases and pregnancy complications Hospitalization chemistry Hyperglycemia Cardiology Myocardial infarction complications Myocardial infarction diagnosis Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation Journal. 78:1475-1480 |
| ISSN: | 1347-4820 1346-9843 |
| DOI: | 10.1253/circj.cj-14-0117 |
| Popis: | Acute kidney injury (AKI) and acute hyperglycemia are associated with unfavorable outcomes. The impact of acute hyperglycemia on the development of AKI after acute myocardial infarction (AMI), however, remains unclear. This study was undertaken to assess the relationship between admission glucose and incidence of AKI after AMI.This study consisted of 760 patients with AMI admitted to the National Cerebral and Cardiovascular Center within 48h after symptom onset. Blood sample was obtained on admission and repeated sampling was done at least every 1 or 2 days during the first week. AKI was diagnosed as increase in serum creatinine ≥0.3mg/dl or ≥50% within any 48h. Ninety-six patients (13%) had AKI during hospitalization for AMI, and these patients had higher in-hospital mortality than those without AKI (25% vs. 3%, P0.001). Patients with AKI had higher plasma glucose (PG) on admission than those without (222±105mg/dl vs. 166±69mg/dl, P0.001). The incidence of AKI increased as admission PG rose: 7% with PG120mg/dl; 9% with PG 120-160mg/dl; 11% with PG 160-200mg/dl; and 28% with PG200mg/dl (P0.01). On multivariate analysis admission PG was an independent predictor of AKI (odds ratio, 1.10; 95% confidence interval: 1.03-1.18, P=0.02).Admission hyperglycemia might have contributed to the development of AKI in patients with AMI. |
| Databáze: | OpenAIRE |
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