Relationship between the adipose-tissue hormone resistin and coronary artery disease
| Autor: | Lorenz Risch, L. Koch, Christoph H. Saely, F. Schmid, Stefan Aczel, Sabine Berchtold, Philipp Rein, Heinz Drexel, G. Hoefle |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Clinical Biochemistry Adipokine Adipose tissue Renal function Lumen (anatomy) Coronary Artery Disease Coronary Angiography Kidney Function Tests Risk Assessment Biochemistry Coronary artery disease Risk Factors Internal medicine Humans Medicine Resistin Aged biology business.industry Biochemistry (medical) C-reactive protein Age Factors Coronary Stenosis nutritional and metabolic diseases General Medicine Middle Aged medicine.disease Coronary Vessels C-Reactive Protein Adipose Tissue biology.protein Cardiology Female business Biomarkers Follow-Up Studies Hormone |
| Zdroj: | Clinica Chimica Acta. 386:1-6 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2007.07.001 |
| Popis: | Data on the cardiovascular risk associated with the adipose-tissue-related hormone resistin are scarce.We measured serum resistin and established vascular risk factors in 547 consecutive patients (age 63+/-10 years) undergoing coronary angiography for the evaluation of stable coronary artery disease. Prospectively, we recorded major coronary events and cumulative vascular events over 4 years.60% of our patients had significant coronary stenoses with a lumen narrowingor =50%. Serum resistin was moderately but significantly correlated with age (r=0.139; p=0.001), high-sensitivity C-reactive protein (hsCRP; r=0.228; p0.001) and decreasing renal function (r=0.240; p0.001). However, there was no significant difference of serum resistin between patients with CAD and those in whom angiography did not show CAD (4.5 [3.1-5.8] vs. 4.3 [3.4-5.3] ng/ml; p=0.545) and between patients withor =50% coronary narrowings and those without such lesions (4.5 [3.2-5.9] vs. 4.3 [3.1-5.5] ng/ml; p=0.265). Prospectively, Cox regression analyses neither indicated an association between serum resistin and major coronary events nor between serum resistin and cumulative vascular events.Among coronary patients serum resistin is significantly correlated with hsCRP, age and decreasing renal function but resistin is neither associated with the presence of significant coronary stenoses nor with the incidence of future vascular events. |
| Databáze: | OpenAIRE |
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