Mechanistic Population Pharmacokinetic Model of Oseltamivir and Oseltamivir Carboxylate Accounting for Physiological Changes to Predict Exposures in Neonates and Infants

Autor:	Barry Clinch, Stefan Sturm, Elke Zwanziger, Leonid Gibiansky, Paul Grimsey, Patanjali Ravva, Neil Parrott, Rajinder Bhardwaj
Rok vydání:	2020
Předmět:	Adult Male Oseltamivir Population Physiology Kidney Antiviral Agents Models Biological 030226 pharmacology & pharmacy Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacokinetics Humans Medicine media_common.cataloged_instance Pharmacology (medical) European union education media_common Pharmacology education.field_of_study Dose-Response Relationship Drug business.industry Research Body Weight Age Factors Infant Newborn Postmenstrual Age Infant Articles Confidence interval Dose–response relationship chemistry 030220 oncology & carcinogenesis Renal physiology Female business
Zdroj:	Clinical Pharmacology and Therapeutics
ISSN:	1532-6535 0009-9236
DOI:	10.1002/cpt.1791
Popis:	A mechanistic population‐pharmacokinetic model was developed to predict oseltamivir exposures in neonates and infants accounting for physiological changes during the first 2 years of life. The model included data from 13 studies, comprising 436 subjects with normal renal function (317 pediatric subjects (≥ 38 weeks postmenstrual age (PMA), ≥ 13 days old) and 119 adult subjects
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3908f8877634f681f71dc7b919354e8 https://doi.org/10.1002/cpt.1791 Zobrazit plný text záznamu Plný text