Immunohistochemical Determination of Estrogen and Progesterone Receptor Status in Breast Cancer
| Autor: | Allam Shawwa, Rosemary Henderson, Marvin Tesch |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Cost-Benefit Analysis Concordance Breast Neoplasms Biology Sensitivity and Specificity Breast cancer Internal medicine medicine Humans Receptor Aged Aged 80 and over Staining and Labeling General Medicine Middle Aged Progesterone Receptor Status medicine.disease Immunohistochemistry Staining Endocrinology Receptors Estrogen Estrogen Fresh frozen Female Receptors Progesterone hormones hormone substitutes and hormone antagonists |
| Zdroj: | American Journal of Clinical Pathology. 99:8-12 |
| ISSN: | 1943-7722 0002-9173 |
| Popis: | Immunohistochemical staining of fresh frozen tissue to identify estrogen and progesterone receptors was tested as a means to supplant the dextran-coated charcoal assay in a small community hospital. Forty-three tumors were compared, yielding an overall concordance of 88% between immunohistochemical staining and the dextran-coated charcoal assay for determination of combined estrogen/progesterone receptor status. In addition, there was greater than 70% concordance for semiquantitative grades. Staining also revealed many other advantages, such as a 65% reduction in costs. For these reasons, the authors have abandoned the dextran-coated charcoal assay in favor of staining for estrogen/progesterone receptor status. |
| Databáze: | OpenAIRE |
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