Polymer coated mucoadhesive liposomes intended for the management of xerostomia
| Autor: | Gro Smistad, Ørjan G. Martinsen, Marianne Hiorth, Małgorzata Adamczak |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Alginates
Polymers Chemistry Pharmaceutical Drug Compounding Pharmaceutical Science 02 engineering and technology 010402 general chemistry 01 natural sciences Xerostomia Chitosan chemistry.chemical_compound Dynamic light scattering Glucuronic Acid Polymer chemistry Zeta potential Humans Particle Size Cellulose chemistry.chemical_classification Liposome Drug Carriers Hexuronic Acids Polymer 021001 nanoscience & nanotechnology 0104 chemical sciences Electrophoresis chemistry Chemical engineering Liposomes Pectins Dynamic vapor sorption Particle size 0210 nano-technology |
| Zdroj: | International journal of pharmaceutics. 527(1-2) |
| ISSN: | 1873-3476 0378-5173 |
| Popis: | The aim of this work was to prepare and test different pharmaceutical formulations in respect of their potential in relieving dry mouth symptom. Since many of the products available on the market provide only temporary relief to the patients, there is need for new formulations able to retain on the oral mucosa. The prolonged moisture protection could be achieved by combining mucoadhesive materials, such as polymers containing hydrogen bonding groups, with vesicles capable of releasing hydration medium from the inner compartment. In this study three different types of liposomes (positively, negatively and neutrally charged) were coated with five different types of polymers: low-methoxylated pectin (LM-pectin), high-methoxylated pectin (HM-pectin), alginate, chitosan and hydrophobically modified ethyl hydroxyethyl cellulose (HM-EHEC). The particle size and the zeta potential of the obtained carriers were tested by measuring dynamic light scattering (DLS) and electrophoretic mobility. Later on, selected positively charged liposomes were deposited on a negatively charged mica surface and depicted by atomic force microscopy (AFM). The water sorption properties of polymers, uncoated liposomes and polymer-coated liposomes were studied by the means of dynamic vapor sorption (DVS). The experiments were performed within the relative humidity range RH = 95–0–95%, at 35 °C. It was found that coating the liposomes with polymers significantly increased the water sorption capacity of the formulations, making them an attractive choice for hydration of the oral mucosa. |
| Databáze: | OpenAIRE |
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