UNEXPECTED RESULTS AND RECOURSE IN PROCESS OPTIMIZATION OF NUCLEOSIDE 3′-O-SUCCINATES
Autor: | Yogesh S. Sanghvi, Quanlai Song |
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Rok vydání: | 2001 |
Předmět: | |
Zdroj: | Nucleosides, Nucleotides and Nucleic Acids. 20:1267-1270 |
ISSN: | 1532-2335 1525-7770 |
Popis: | An improved and scalable protocol for the synthesis of 3'-O-succinates of nucleosides has been developed using succinic anhydride. As a result, formation of unwanted dimer has been completely eliminated and use of toxic and smelly reagents have been avoided during synthesis of nucleoside succinates. All succinates were isolated in pure state without silica gel column chromatography. |
Databáze: | OpenAIRE |
Externí odkaz: | |
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