UNEXPECTED RESULTS AND RECOURSE IN PROCESS OPTIMIZATION OF NUCLEOSIDE 3′-O-SUCCINATES

Autor:	Yogesh S. Sanghvi, Quanlai Song
Rok vydání:	2001
Předmět:	Chemistry Silica gel Dimer Succinic anhydride Nucleosides Succinates General Medicine Biochemistry chemistry.chemical_compound Column chromatography Reagent Chromatography Gel Genetics Molecular Medicine Organic chemistry Nucleoside
Zdroj:	Nucleosides, Nucleotides and Nucleic Acids. 20:1267-1270
ISSN:	1532-2335 1525-7770
Popis:	An improved and scalable protocol for the synthesis of 3'-O-succinates of nucleosides has been developed using succinic anhydride. As a result, formation of unwanted dimer has been completely eliminated and use of toxic and smelly reagents have been avoided during synthesis of nucleoside succinates. All succinates were isolated in pure state without silica gel column chromatography.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3905277f182e2ad8943a0ab906004db https://doi.org/10.1081/ncn-100002533 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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