| Autor: |
Benedikt Schmidl, Kim-Aylin Voßenkämper, Leonhard Stark, Melanie Boxberg, Fabian Stögbauer, Katharina Feigl, Christof Winter, Anja Pickhard, Barbara Wollenberg, Markus Wirth |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. |
| ISSN: |
1434-4726 |
| Popis: |
Purpose The tumorigenesis of squamous cell cancer of unknown primary (SCCUP) in the head and neck area has not been decoded so far, while poor survival rates and limited therapeutic options pose a serious challenge. The aim of this project was to investigate immunological characteristics of SCCUPs and compare them to oropharyngeal squamous cell carcinoma (OPSCC). Methods PD-L1 expression (TC) was examined by immunohistochemistry in 50 lymph node metastases of SCCUP and 47 primaries of OPSCC. CD3 + and CD8 + lymphocytic infiltration was measured in 5 high power fields. Expression of p16 and HPV ISH were assessed. Results SCCUP demonstrated a significantly higher expression of PD-L1 than OPSCC. In p16-negative SCCUPs PD-L1 proved to be an independent prognostic factor to prioritize high-risk patients. Conclusions Immunologic differences between SCCUP and OPSCC were detected. A higher PD-L1 expression in SCCUP could potentially facilitate further evaluation of checkpoint inhibitor therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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