The comparative in vitro pharmacology of leukotriene D4 and its isomers
| Autor: | David J. Osborne, W.John F. Sweatman, Jamieson William B, John R. Boot, S. Richard Baker |
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| Rok vydání: | 1981 |
| Předmět: |
Leukotriene D4
Double bond Stereochemistry Guinea Pigs Biophysics Biochemistry Structure-Activity Relationship chemistry.chemical_compound Isomerism Smooth muscle Ileum medicine Animals Structure–activity relationship Bioassay Molecular Biology chemistry.chemical_classification Biological activity Cell Biology respiratory system In vitro pharmacology chemistry Biological Assay SRS-A lipids (amino acids peptides and proteins) medicine.symptom Muscle Contraction Muscle contraction |
| Zdroj: | Biochemical and Biophysical Research Communications. 103:1258-1264 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(81)90258-8 |
| Popis: | The 5R,6S and 5S,6R isomers of leukotriene D4 (LTD4), 9cis LTD4, 9cis,11trans LTD4 and 11trans LTD4 were synthesized for comparative pharmacological studies on intestinal and respiratory smooth muscle preparations. The 5S,6R isomers are biologically active, modification of the double bond stereochemistry causing only a moderate reduction in activity. The 5R,6S isomers possess approximately 1% the biological activity of their respective 5S,6R forms. |
| Databáze: | OpenAIRE |
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