The Dose-Response Relationship Between Influenza Viruses and the Surviving Allantois

Autor:	D. O. White, S. Fazekas De St. Groth
Rok vydání:	1958
Předmět:	Infectivity Epidemiology Orthomyxoviridae Immunologic Tests Embryo Allantois Articles Biology Chick embryos biology.organism_classification Dental care Virology Dose–response relationship Infectious Diseases medicine.anatomical_structure Research Design Immunology medicine Humans Dental Care
Zdroj:	Epidemiology and Infection. 56:523-534
ISSN:	1469-4409 0950-2688
DOI:	10.1017/s0022172400038018
Popis:	It is shown that bits of allantois-on-shell cut from any one egg do not differ either in susceptibility to infection by influenza viruses or in yield of haemagglutinin. For this reason the dose-response curve within any egg is Poissonian.Bits cut from different eggs vary both in susceptibility and in haemagglutinin yield. Unlike in whole eggs however, the scatter is so small that it can be demonstrated only by refined tests done on a large number of subjects. For practical purposes the dose-response curve may still be taken as Poissonian.Susceptibility and yield vary independently of one another.The data are used to define the accuracy of infectivity tests in bits of allantois-on-shell; the expected errors are given both for straight replication and for tests done with different reagents, by different operators, or at different times.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38f81f232674f8c0f4ed9da29691b41 https://doi.org/10.1017/s0022172400038018 Zobrazit plný text záznamu