Prognostic Impact of PHIP Copy Number in Melanoma: Linkage to Ulceration
| Autor: | Suresh Thummala, James E. Cleaver, Vladimir Bezrookove, Altaf A. Dar, Mehdi Nosrati, David de Semir, Mohammed Kashani-Sabet, Schuyler Tong, Clayton Wu, Richard W. Sagebiel, James R. Miller, Stanley P. L. Leong |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology Skin Neoplasms Angiogenesis Nude Gene Dosage Kaplan-Meier Estimate Biochemistry Mice chemistry.chemical_compound 0302 clinical medicine Melanoma Cancer 0303 health sciences Tumor Tissue microarray medicine.diagnostic_test Intracellular Signaling Peptides and Proteins Middle Aged Prognosis Vascular endothelial growth factor 030220 oncology & carcinogenesis Female Adult medicine.medical_specialty Clinical Sciences Oncology and Carcinogenesis Mice Nude Dermatology Biology Gene dosage Article Cell Line 03 medical and health sciences In vivo Cell Line Tumor Lactate dehydrogenase Skin Ulcer Biomarkers Tumor medicine Animals Humans Molecular Biology Aged 030304 developmental biology Dermatology & Venereal Diseases Cell Biology medicine.disease digestive system diseases chemistry Cancer research Biomarkers Neoplasm Transplantation Fluorescence in situ hybridization |
| Zdroj: | The Journal of investigative dermatology The Journal of investigative dermatology, vol 134, iss 3 |
| ISSN: | 0022-202X |
| DOI: | 10.1038/jid.2013.369 |
| Popis: | Ulceration is an important prognostic factor in melanoma whose biologic basis is poorly understood. Here we assessed the prognostic impact of pleckstrin homology domain-interacting protein (PHIP) copy number and its relationship to ulceration. PHIP copy number was determined using fluorescence in situ hybridization (FISH) in a tissue microarray cohort of 238 melanomas. Elevated PHIP copy number was associated with significantly reduced distant metastasis-free survival (DMFS; P=0.01) and disease-specific survival (DSS; P=0.009) by Kaplan-Meier analyses. PHIP FISH scores were independently predictive of DMFS (P=0.03) and DSS (P=0.03). Increased PHIP copy number was an independent predictor of ulceration status (P=0.04). The combined impact of increased PHIP copy number and tumor vascularity on ulceration status was highly significant (P |
| Databáze: | OpenAIRE |
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