| Popis: |
Percutaneous-based PDA closure is technically feasible among infants ≤1.5 kg. However, marked heterogeneity in the type and nature of adverse events, such as anesthesia-related complications, obscure current safety profile assessments. While data on the risks of post-device closure syndrome (PDCS) remain promising, a lack of comparative trials of surgical ductal ligation and inconsistent surveillance across published studies obscure confidence in present estimates of safety and efficacy. To minimize risk and yield the greatest benefits, clinical studies of PDA treatment should consider incorporating more robust assessments (e.g., PDA scores) to ensure that infants at greatest risk for adverse ductal consequences are included. |
