Factors affecting complications development and mortality after single lung transplant
| Autor: | Bilyana Simonska, Boris Krastev, Monika Peshevska-Sekulovska, Milena Peruhova, Metodija Sekulovski, Lubomir Spassov, Tsvetelina Velikova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Native lung complications
medicine.medical_specialty genetic structures Single lung transplant De novo malignancy medicine.medical_treatment Primary Graft Dysfunction Review Anastomosis Malignancy medicine Lung transplantation Transplantation Lung business.industry Incidence (epidemiology) Primary graft dysfunction Immunosuppression Technical transplant complications medicine.disease Surgery medicine.anatomical_structure Vascular transplant complications Graft rejection business |
| Zdroj: | World Journal of Transplantation |
| ISSN: | 2220-3230 |
| DOI: | 10.5500/wjt.v11.i8.320 |
| Popis: | Lung transplantation (LT) is a life-saving therapeutic procedure that prolongs survival in patients with end-stage lung disease. Furthermore, as a therapeutic option for high-risk candidates, single LT (SLT) can be feasible because the immediate morbidity and mortality after transplantation are lower compared to sequential single (double) LT (SSLTx). Still, the long-term overall survival is, in general, better for SSLTx. Despite the great success over the years, the early post-SLT period remains a perilous time for these patients. Patients who undergo SLT are predisposed to evolving early or late postoperative complications. This review emphasizes factors leading to post-SLT complications in the early and late periods including primary graft dysfunction and chronic lung allograft dysfunction, native lung complications, anastomosis complications, infections, cardiovascular, gastrointestinal, renal, and metabolite complications, and their association with morbidity and mortality in these patients. Furthermore, we discuss the incidence of malignancy after SLT and their correlation with immunosuppression therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|