Gastrodin attenuates vincristine-induced mechanical hyperalgesia through serotonin 5-HT1A receptors
| Autor: | Jian-hua Hao, Zhenggang Guo, Xiao-pen Jia, Xiaojun Su, Ping Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Vincristine
medicine.drug_class Analgesic Pharmacology Neuropathic pain chemistry.chemical_compound Gastrodin Mice medicine Receptor biology business.industry lcsh:RM1-950 Von frey filament biology.organism_classification Receptor antagonist Gastrodia elata lcsh:Therapeutics. Pharmacology chemistry Serotonin business medicine.drug |
| Zdroj: | Bangladesh Journal of Pharmacology, Vol 8, Iss 4, Pp 414-419 (2013) Bangladesh Journal of Pharmacology, Vol 8, Iss 4 (2013) |
| ISSN: | 1991-0088 |
| Popis: | Gastrodia elata Blume (Orchidaceae) is an old traditional Chinese medicine with demonstrated analgesic efficacy in humans. However, the potential analgesic effect of its active component, gastrodin, has not been systematically studied. This work described the anti-hyperalgesic effect of gastrodin in a mouse model of chemotherapeutic agent vincristine-induced neuropathic pain. Gastrodin (0.05-0.8 mg/kg) dose-dependently reverted the mechanical hyperalgesia in mice. In addition, the anti-hyperalgesic effect of gastrodin was significantly blocked by a selective serotonin 5-HT 1A receptor antagonist WAY100635 (1 mg/kg). In contrast, gastrodin did not significantly alter the general locomotor activity in mice. Taken together, this study demonstrated that gastrodin possesses robust analgesic efficacy in mice and may be a novel analgesic for the management of neuropathic pain. DOI: http://dx.doi.org/10.3329/bjp.v8i4.16836 Bangladesh Journal of Pharmacology Vol.8(4) 2013 414-419 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|