Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms
| Autor: | Roberto Lin, Karen Nygard, Xiang-Jiao Yang, Frankie Eng, Yolande Bastien, Nicholas Bertos, Nadine Pelletier, Isabelle Fernandes, Olivier Cormier, John H. White, Han S. Lee, Sylvie Mader, Victor K. M. Han, Timothy Wai |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Transcriptional Activation Placenta Recombinant Fusion Proteins Amino Acid Motifs Molecular Sequence Data Biology Hydroxamic Acids Ligands Histone Deacetylases Nuclear Receptor Coactivator 2 Fetus Genes Reporter Two-Hybrid System Techniques Coactivator medicine Tumor Cells Cultured Animals Humans Amino Acid Sequence Enzyme Inhibitors Molecular Biology In Situ Hybridization Binding Sites Estrogen Receptor alpha Nuclear Proteins Cell Biology Molecular biology Cell biology Histone Deacetylase Inhibitors Repressor Proteins Trichostatin A Nuclear receptor Receptors Estrogen COS Cells Nuclear receptor coactivator 2 Histone deacetylase LCOR Corepressor Estrogen receptor alpha Sequence Alignment medicine.drug Protein Binding Transcription Factors |
| Zdroj: | Molecular cell. 11(1) |
| ISSN: | 1097-2765 |
| Popis: | LCoR (ligand-dependent corepressor) is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LXXLL motif. LCoR binding to estrogen receptor alpha depends in part on residues in the coactivator binding pocket distinct from those bound by TIF-2. Repression by LCoR is abolished by histone deacetylase inhibitor trichostatin A in a receptor-dependent fashion, indicating HDAC-dependent and -independent modes of action. LCoR binds directly to specific HDACs in vitro and in vivo. Moreover, LCoR functions by recruiting C-terminal binding protein corepressors through two consensus binding motifs and colocalizes with CtBPs in the nucleus. LCoR represents a class of corepressor that attenuates agonist-activated nuclear receptor signaling by multiple mechanisms. |
| Databáze: | OpenAIRE |
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