Substantial Variation in Transplacental Transfer of Chemotherapeutic Agents in a Mouse Model
| Autor: | Kristel Van Calsteren, Ernst A. de Bruijn, Jan de Hoon, Rieta Van Bree, Frédéric Amant, Liesbeth Heyns, René Verbesselt |
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| Přispěvatelé: | Other departments |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Paclitaxel Placenta medicine.medical_treatment Antineoplastic Agents Gestational Age Pharmacology Vinblastine High-performance liquid chromatography Carboplatin Mice chemistry.chemical_compound Pharmacokinetics Pregnancy medicine Animals Maternal-Fetal Exchange Epirubicin Gynecology Chemotherapy business.industry Cytarabine Obstetrics and Gynecology Transplacental Fetal Blood Mice Inbred C57BL chemistry Doxorubicin Injections Intravenous Models Animal Female business medicine.drug |
| Zdroj: | Reproductive sciences (Thousand Oaks, Calif.), 18(1), 57-63. SAGE Publications Inc. |
| ISSN: | 1933-7205 1933-7191 |
| DOI: | 10.1177/1933719110379650 |
| Popis: | Objective: Data on the transplacental transfer of chemotherapeutic agents are lacking. We aimed to measure the maternofetal transfer of cytotoxic drugs in a mouse model. Study design: The transplacental transfer of doxorubicin (9 mg/kg), epirubicin (11 mg/kg), vinblastine (6 mg/kg), carboplatin (50 mg/kg), paclitaxel (10 mg/kg), and cytarabine (100 mg/kg) was tested in a C57/Bl6J mouse model. Ninety minutes after intravenous (IV) drug injection on gestational day 18.5, maternal and fetal blood were collected simultaneously. Plasma drug levels were determined using high performance liquid chromatography or atomic absorption spectrometry. Results: Fetal plasma concentrations of doxorubicin, epirubicin, vinblastine, and cytarabine were 5.1% +/- 0.6% (n = 8), 4.8% +/- 3.8% (n = 8), 13.8% +/- 5.8% (n = 6), and 56.7% +/- 22.6% (n = 6) of the maternal concentrations, respectively. Total platinum passed the mouse placenta easily (117.0% +/- 38.9%, n = 6). Paclitaxel could not be detected in fetal plasma samples (n 6). Conclusions: Substantial variations in transplacental transfer were noted among the tested drugs. Current findings contribute to the understanding of reported pregnancy outcomes in humans |
| Databáze: | OpenAIRE |
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