Effect of a terpenoid, (—)-6-Hydroxy-4-(1-hydroxy-1-methylethyl)-1-cyclohexene-1-ethanol, on drug-metabolizing enzymes and glutathione content in rat liver and lung
| Autor: | P. G. Gervasi, A. Lippi, Giuseppe Bellucci, F. Luzzani, P. Ventura, Franco Marioni |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Ketone Health Toxicology and Mutagenesis Biology Toxicology Biochemistry chemistry.chemical_compound Cytochrome P-450 Enzyme System In vivo Oral administration Cyclohexenes Animals Lung Pharmacology chemistry.chemical_classification Ethanol Terpenes Rats Inbred Strains Biological activity General Medicine Glutathione Ketones Cyclohexanols Terpenoid Rats Enzyme Liver Pharmaceutical Preparations chemistry Oxidoreductases |
| Zdroj: | Xenobiotica. 21:141-145 |
| ISSN: | 1366-5928 0049-8254 |
| Popis: | 1. Chronic treatment of Sprague-Dawley rats with the new terpenoid mucoregulating drug (I) did not modify activities of the drug-metabolizing enzymes (phase I and phase II) of liver and lung. 2. Acute treatment of rats with I did not affect the GSH content of liver and lung, but administration of the corresponding alpha, beta-unsaturated ketone (II) produced considerable GSH depletion in both tissues, the original GSH levels being restored after a few hours. 3. The results are discussed in comparison with those previously obtained with the structurally related drug trans-sobrerol (III). |
| Databáze: | OpenAIRE |
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