Gender-related differences in susceptibility, early virus dissemination and immunosuppression in mice infected with Friend murine leukaemia virus variant FIS-2
| Autor: | Liss Anne S. Lavik, Lena Irene Kristiansen, Hong Yan Dai, Are Dalen, Torunn Bruland |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Time Factors viruses medicine.medical_treatment Spleen Viremia Biology Virus Immune tolerance Sex Factors Bone Marrow Virology Immune Tolerance medicine Animals Recombination Genetic Leukemia Experimental Immunosuppression medicine.disease Friend murine leukemia virus Tumor Virus Infections Leukemia medicine.anatomical_structure Viral replication Immunology Female Bone marrow Retroviridae Infections |
| Zdroj: | Journal of General Virology. 82:1821-1827 |
| ISSN: | 1465-2099 0022-1317 |
| Popis: | An emerging amount of data indicates a correlation between gender-related factors and regulation of virus infection and supports what is known in clinical circles, that these topics are of great importance in many infectious diseases. In the present study we found that young adult NMRI male mice are more susceptible to infection by a variant of Friend murine leukaemia virus, FIS-2, than are female mice. We observed that the level of virus in serum, bone marrow and spleen was initially higher in male mice. Male mice were also more susceptible to FIS-2-induced immunosuppression. These results indicate a more efficient virus replication and dissemination in male mice. Studies with recombinant viruses between FIS-2 and the prototype Friend murine leukaemia virus revealed that FIS-2 LTR is one major factor contributing to the observed gender differences. A possible sex hormone influence on FIS-2 transcription due to the presence of a glucocorticoid response element in FIS-2 LTR is discussed. |
| Databáze: | OpenAIRE |
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